Tetraacetylphytosphingosine-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemETetraacetylphytosphingosineCat.No.:HY-138875CASNo.:13018-48-9分子式:C₂₆H₄₇NO₇分子量:485.65作用靶点:p38MAPK;Apoptosis作用通路:MAPK/ERKPathway;Apoptosis储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Tetraacetylphytosphingosine是一种由植物鞘氨醇乙酰化产生的鞘脂代谢物。Tetraacetylphytosphingosine通过抑制MAPK活化和细胞内钙离子增加发挥抑制血管生成的作用。Tetraacetylphytosphingosine诱导HaCaT细胞凋亡(apoptosis)。体外研究Tetraacetylphytosphingosine(TAPS;5μM;24h)markedlydecreasesVEGF-inducedchemotacticmigrationandcapillary-liketubeformationinHUVEC.TetraacetylphytosphingosinesignificantlyinhibitsVEGF-inducedproteolyticenzymeproduction,includingMMP-2,urokinase-typeplasminogenactivator(uPA)andplasminogenactivatorinhibitor-1(PAI-1).TetraacetylphytosphingosinealsosuppresseSVEGF-inducedphosphorylationofp42/44extracellularsignal-regulatedkinaseandc-JNK[1].Inaddition,TetraacetylphytosphingosineabolishedVEGF-inducedintracellularcalciumincrease[1].InHaCaTcells,Tetraacetylphytosphingosineco-treatmentsynergisticallyincreasesthelevelofUVB-inducedapoptosisviacaspaseactivationbyregulatingthelevelofpro-apoptoticBaxandanti-apoptoticBcl-2[2].WesternBlotAnalysis[1]CellLine:HUVECConcentration:5μMIncubationTime:24hResult:MarkedlyinhibitsVEGF-inducedproteolyticenzymeproduction,includingMMP-2,uPAandPAI-1.1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemEREFERENCESYooBinKwon,etal.Anti-angiogeniceffectoftetraacetyl-phytosphingosine.ExpDermatol.2007Apr;16(4):311-7.HJKim,etal.PotentiationofUVB-inducedapoptosisbynovelphytosphingosinederivative,tetraacetylphytosphingosineinHaCaTcellandmouseskin.Apoptosis.2004Jul;9(4):449-56.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3