IOWH-032 - CFTR 抑制剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEIOWH-032Cat. No.: HY-18337CAS No.: 1191252-49-9分式: CHBrNO分量: 545.18作靶点: CFTR作通路: Membrane Transporter/Ion Channel储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (183.43 mM)* means

2、 soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.8343 mL 9.1713 mL 18.3426 mL5 mM 0.3669 mL 1.8343 mL 3.6685 mL10 mM 0.1834 mL 0.9171 mL 1.8343 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您

3、现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (4.59 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (4.59 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL

4、ACTIVITY物活性 IOWH-032是CFTR抑制剂，在T84和CHO-CFTR细胞实验中IC50为1.01 uM。户使本产品发表的科研献 Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L192-207.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Doyle K, et al. Inhibitors Of The CFTR Chloride Ion Channel As Potential Treatment For Acute Se

5、cretory Diarrhea: Development Of 5-membered Heterocycles Suitable For Pre-clinical Evaluation2. de Hostos EL, et al. Developing novel antisecretory drugs to treat infectious diarrhea. Future Med Chem. 2011 Aug;3(10):1317-25.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-589