2019年生物发酵产品目前能达到的水平参考大全

1、生物发酵产品目前能到达的水平参考大全点击数：404发布时间：2009年9月13日来源：cnenzyme进入论坛交流ITEMSTECHDATAREMARKSIMMUNOSUPPRESSIVEAGENT他克莫司TacrolimusFinalTitre:600-700mg/LFermentationtime:168hrsRecovery:40%FK506霉酚酸MycophenoicacidFinalTitre:15g/LFermentationtime:264hrsRecovery:70%IntermediateforMMF环抱菌素ACyclosporinAFinalTitre:10g/LFerme

2、ntationTime:168hrsRecovery:70%雷帕霉素(西罗莫司)Rapamycin(Sirolimus)FinalTitre:600-800g/LFermentationTime:216hrsRecovery:60%OrintermediateforZotarolimus,Everolimusand子囊霉素AscomycinFinalTitre:500g/LFermentationTime:216hrsRecovery:60%FK520OrIntermediateforPimecrolimusANTIBIOTICS阿莫西林AMOXICILLINByenzymeprocess万古

3、霉素VancomycinFinalTitre:9-10g/LFermentationTime:150hrsRecovery:>70%士七jq产f替考拉丁TeicoplaninFinalTitre:4-5g/LFermentationTime:150hrsRecovery:>70%达托霉素DaptomycinFinalTitre2.0g/LFermentationTime:200hrsRecovery:>40%Orcubicin莫匹罗星MupirocinFinalTitre:4-5g/LFermentationTime:60-70hrsRecovery:>75%Pneum

4、ocandinB0FinalTitre:1.7g/LFermentationTime:11-12daysRecovery:>60%Caspofungin雷莫拉宁RamoplaninFinalTitre:3g/LFermentationTime:200hrsRecovery:>60%普那霉素原始霉素PristinamycinFinalTitre:8/LFermentationTime:150hrsRecovery:>70%克拉维酸棒酸ClavulanicacidFinalTitre:6g/LFermentationTime:105hrsRecovery:55%头抱菌素CCeph

5、alosporinCFinalTitre:40g/LFermentationTime:168hrsRecovery:80%各种头抱类中间体青霉素GPenicillinGFinalTitre:120000g/LFermentationTime:220hrsRecovery:80%红霉素ErythromycinFinalTitre:9-10g/LFermentationTime:156hrsRecovery:60%依托红霉素、琥乙红霉素、地红霉素、罗红霉素、阿奇霉素和克拉霉素的中间体去甲金霉素Demethylchlortetracycline(DMCT)FinalTitre:16g/LFermen

6、tationTime:200hrsRecovery:75%IntermediateforMinocycline,Tigecylcine林可霉素洁霉素LincomycinFinalTitre:9-10g/LFermentationTime:200hrsRecovery:80-90%克林霉素中间体Clindamycin杆菌肽BacitracinFinalTitre:1200U/mlFermentationTime:50-60hrsRecovery:95%ZincBacitracinforAnimalfeedadditive那西肽NosiheptideFinalTitre:1700-2000U/ml

7、FermentationTime:50hrsRecovery:95%Animalfeedadditive两性霉素BAmphotericinBFinalTitre:10000U/mlFermentationTime:130-140hrsRecovery:75%阿维拉霉素卑霉素AvilamycinFinalTitre:7-8g/LFermentationTime:268hrsRecovery:95%Animalfeedadditive恩拉霉素EnramycinFinalTitre:8-10g/LFermentationTime:260hrsRecovery:95%Animalfeedadditiv

8、e卡那霉素KanamycinFinalTitre:25g/LFermentationTime:240hrsRecovery:85%卷曲霉素CapreomycinFinalTitre:11000U/mlFermentationTime:150-160hrsRecovery:75%庆大霉素CGentamicinCFinalTitre:5-6g/LFermentationTime:14daysRecovery:75%庆大霉素BGentamycinBFinalTitre:1000Mmg/LFermentationTime:120-130hrsRecovery:75%异帕米星Isepamicin多粘菌素

9、BPolymyxinBFinaltitre2.5g/lFermentationtime72hrsRecoveryyield70%粘杆菌素EPolymyxinEFinaltitre600000U/mlFermentationtime96hrsRecoveryyield75%泰乐菌素TylosinFinaltitre15000U/lFermentationtime180hrsRecoveryyield70%巴龙霉素ParomomycinFinaltitre8g/lFermentationtime170hrsRecoveryyield70%制霉菌素NystatinFinaltitre300,000I

10、U/mlFermentationtime280hrsRecoveryyield85%盐霉素SalinomycinFinaltitre80g/lFermentationtime268hrsRecoveryyield90%金霉素ChlortetracyclineFinaltitre50g/lFermentationtime200hrsRecoveryyield90%四环素TetracyclineFinaltitre40g/lFermentationtime200hrsRecoveryyield90%土霉素OxytetracyclineFinaltitre40g/lFermentationtime2

11、00hrsRecoveryyield90%链霉素StreptomycinFinaltitre28,000U/mlFermentationtime200hrsRecoveryyield80%利福霉素RifamycinFinaltitre30g/lFermentationtime220hrsRecoveryyield75%黄霉素FlavomycinFinaltitre8g/lFermentationtime168hrsRecoveryyield90%截短侧耳素PleuromutilinFinaltitre14000U/mlFermentationtime300hrsRecoveryyield80%

12、泰妙菌素Tiamulin大观霉素SpectinomycinFinaltitre7000-10000U/mlFermentationtime130-150hrsRecoveryyield70%莫能菌素Monensin38000u/mlFinaltitre6500-8000U/mlFermentationtime140-170hrsRecoveryyield70-80%妥布霉素TobramycinFinaltitre6500-8000U/mlFermentationtime140-170hrsRecoveryyield70-80%安普霉素ApramycinFinaltitre6500-8000U/

13、mlFermentationtime140-170hrsRecoveryyield70-80%尼可霉素NikkomycinFinaltitre7-8g/lFermentationtime70hrsRecoveryyield80%麦角酸LysergicacidFinaltitre7-8g/lFermentationtime360hrsRecoveryyield70%Forcabergolineandnicergoline夫西地酸FusidicAcidFinaltitre4-5g/lFermentationtime200hrsRecoveryyield40%麦迪霉素MedimycinFinalti

14、tre18g/lFermentationtime200hrsRecoveryyield75%莫能菌素MonensinFinalTitre:40000U/mlFermentationTime:300hrsRecovery:95%马杜霉素MaduramicinFinalTitre:612000U/mlFermentationTime:200hrsRecovery:95%利福霉素RIFAMYCINFinalTitre:25g/LFermentationTime:240hrsRecovery:80%磷霉素Fosfomycin氯霉素Chloramphenicol灰黄霉素Griseofulvin螺旋霉素S

15、piramycinRovamycinFinalTitre:6000U/mlFermentationTime:160hrsRecovery:75%小诺霉素Micronomicin维吉尼亚霉素VirginmycinR&D亮菌甲素假蜜环菌素Armillarisina.美贝霉素MilbemycinSeeking莫西菌素Moxidectin道拉困素Doramectin学习文档仅供参考土拉霉素TulathromvcinSeeking米卡芬净micafunginR&D阿尼芬净anidulafunginR&D阿维菌素AbamectinFinalTitre:4.5g/lFlask:4.8

16、-5.0g/LTime:240hrsRecovery:80%Includingitsderivatives多杀菌素SpinosadFinalTitre:12g/LFermentationTime:200-240hrsRecovery:80%Bio-pesticide井冈霉素ValidamycinFinalTitre:3-4g/LBiopesticide学习文档仅供参考FermentationTime:60-70hrsRecovery:80%春雷霉素KasugamycinFinalTitre:8000-1000U/mlFermentationTime:192hrsRecovery80%多抗霉素P

17、olyoxinFinalTitre:5000U/mlFermentationTime:192hrsRecovery:80%脱落酸AbscisicAcid(ABA)FinalTitre:1.6g/LFermentationTime:70-72hrsRecovery:60-65%Planthormone赤霉素Gibberellin(GA3)FinalTitre:2.5-2.8g/LFermentationTime:150-160hrsRecovery:80%中生霉素zhongshengmycinFinalTitre:10g/LFermentationTime:1200hrsRecovery:80%

18、枯草芽抱杆菌BacillussubtilisFinalTitre6000U/mlFermentationTime:150-160hrsRecovery:80%苏云金杆菌BacillusthuringiensisFinalTitre:5500g/mlFermentationTime:150-160hrsRecovery:80%浏阳霉素Liuyangmycin宁南霉素Ningnanmycin链霉素streptomycinForagricultureANTI-DIABETES米格列醇MiglitolFinalTitre:2g/LFermentationTime:70-72hrsRecovery:60

19、-65%Synthesis:90%阿卡波糖AcarboseFinalTitre:5-6g/LFermentationT,ime:130-150hrsRecovery:30-40%伏格列波糖VegliboseChemicalsynthesisANTI-TUMOR柔红霉素DaunomycinFinalTitre:1.5g/LFermentationTime:168hrsRecovery:>67%Forepirubicin,Idarubicin,doxorubicin洋红霉素CarminomycinFinaltitre0.15g/lFermentationtime168hrsRecoveryy

20、ield65%偏端霉素DistamycinFinaltitre2g/lFermentationtime120hrsRecoveryyield52%博莱霉素BleomycinFinaltitre4g/lFermentationtime168hrsRecoveryyield70%紫杉醇PaclitaxelFinaltitre200mg/lFermentationtime120hrsRecoveryyield50%丝裂霉素CMitomycinCFinaltitre1000mg/lFermentationtime200hrsRecoveryyield50%阿霉素DoxorubicinChemicals

21、ynthesisOrfermentation棕霉素BruneomycinFinaltitre150mg/lFermentationtime144hrsRecoveryyield60%放线菌素DDactinomycinDChemicalsynthesis表阿霉素EpirubicinChemicalsynthesis伊达比星IdarubicinChemicalsynthesis毗柔比星PirarubicinChemicalsynthesis学习文档仅供参考ANTI-CARDIVASCULAR洛伐他汀LovastatinFinalTitre:16g/LFermentationTime:168hrsR

22、ecovery:70%美伐他汀CompactinFinalTitre:10g/LFermentationTime:200-220hrs普伐他汀PravastatinFinalTitre:8.0g/lConversionrate:70%Cycletime:120-144阿托伐他汀AtorvastatinChemicalsynthesis瑞舒伐他汀RosuvastatinChemicalsynthesis辛伐他汀SimvastatinChemicalsynthesis氟伐他汀FluvastatinChemicalsynthesisORGANNICACIDBiobasedchemicals衣康酸It

23、aconicAcidAcid:>6%Cycletime:40-50hrsConversion:>50%Fermentationdata:1.4g/L/hrTheproductgetstoPfizer柠檬酸Citricacid莽草酸ShikimicAcidTitre:25g/LL-乳酸L-LacticacidAcid:16-18%Conversionrate;90%丙酮酸PyruvicacidTitre:55-65g/LConversionrate:55-60%Fermentationtime:60hrRecovery:70%长链二元酸Long-chaindicarbxylicaci

24、dDCA13-18:180g/L,Fermentationtime:5-6daysBio-basedproducts1,3-丙二醇1,3-propandiol(PDO)Titre:85g/LConversionrate:60%Productivity:1.2-1.4g/LHChemical2,3-丁二醇2,3-butandiol50-65g/LByproductfromPDO丁醇Butanol20g/L甘油GlycerolTitre:160g/lTime:78hrsProductivity:2g/LHMassconversionrate:48.6%Chemical丙烯酰胺AcrylamideE

25、nzymeactivity:10g/mlAcrylonitrileconsumption:0.75t/tConversionrate:99.9%Chemical烟酰胺NicotinamideEnzymeactivity:8g/mlNicotinonitrileconsumption:0.85t/tConversionrate:99.999%Assay:100%Chemical羟基乙酸HydroxyaceticacidEnzymeactivity:0.1g/mlGlycolonitrileconsumption:0.78t/tConversionrate:99.9%Assay:99.5%(pha

26、rmagrade)Chemical黄原胶XanthanFinalTitre:5-6g/LFermentationTime:36hrsRecovery:80%琥珀酸丁二酸Succinicacid苹果酸Malicacid牛磺酸Taurine乙酸醋酸Aceticacid聚羟基脂肪酸Polyhydroxyalkanoates(PHAs)degradableplastics聚乳酸Polylacticacid,PLAVITAMINANDCAROTENOID维生素B2VitaminB2Finaltitre30g/lFermentationtime72hrsRecoveryyield80%维生素B12Vita

27、minB12Finaltitre250mg/lTIME:180hrs维生素CVitaminCFinaltitre11-12g/lFermentationtime60hrsConversionrate;90%番茄红素LycopeneFinalTitre:>1.0g/L胡萝卜素BetaCaroteneFinalTitre:2.5-3.0g/LFermentationTime:72hrsRecovery:75-80%虾青素AstaxanthinFinalTitre:2g/L维生素D2VitaminD2Lightreaction维生素D3VitaminD3Lightreaction维生素AVit

28、aminAchemicalsynthesis维生素HVitaminHByfermentationOrchemicalsynthesisBiotinHORMONEBiotransformationHormone雄烯二酮Anostenedione(AD)Finaltitre15g/lFermentationtime200hrsRecoveryyield75%Intermediate雄二烯二酮androsta-1,4-diene-3,17-dione(ADD)Finaltitre10g/lFermentationtime200hrsRecoveryyield72%Intermediate泼尼松龙Pr

29、ednisoloneFinaltitre>20g/L(Maximum70g/L)time：5-8hrsconversion:97100%睾丸素TestosteroneFinalTitre5g/L去氢甲睾酮MethandrostenoloneFinalTitre10g/LPregna1,4,9,17acetateFinalTitre5g/LPregna1,2,9,21FinalTitre5g/L螺内酯SPIRONOLACTONE依普利酮EplerenoneANTISPETIC异抗血酸D-isoascorbateProductivity:18-20g/L那他霉素NatamycinFinalTitre:8-10g/LFermentationTime:140-150hrsantiseptic乳酸链球菌素NisinNaturalantisepticHEALTHCARE谷胱甘肽Glutathione(GSH)T