Adenosine-dialdehyde-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAdenosine dialdehydeCat. No.: HY-123055CAS No.: 34240-05-6分式: CHNO分量: 265.23作靶点: Nucleoside Antimetabolite/Analog作通路: Cell Cycle/DNA Damage储存式: Please store the product under the recommended conditions inthe COA.溶解性数据体外实验 DMSO :

2、 10 mg/mL (37.70 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.7703 mL 18.8516 mL 37.7031 mL5 mM 0.7541 mL 3.7703 mL 7.5406 mL10 mM 0.3770 mL 1.8852 mL 3.7703 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Adenosine Dialdehyde嘌呤核苷的类似物，S-腺苷同型半胱氨酸解酶 (SA

3、H) 的不可逆抑制剂 (IC50=40nM)。Adenosine Dialdehyde 具有较强的抗肿瘤活性，可于肿瘤研究。体外研究 Adenosine dialdehyde suppresses MNB cell replication in tissue culture with concentra tions of 1.5 M withproducing 50% inhibition 1.体内研究Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; infused over a 7-day period ( minipu

4、mpinfusion) significantly increases the mean life span of tumor bearing mice from 20.9 days in diluent treatedcontrols to 35.3 days in AD treated animals 2.Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg;1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEtwo 7-day periods interspersed by a

5、 7-day drug free interval( minipump infusion)increases mean life span80% in diluent treated controls (controls, 21.3 days; AD treated 38.4 days) in mice 2.Adenosine dialdehyde(subcutaneous injection; 2-3 mg/kg; infused over a 7-day period ( minipump infusion) does not exhibit anyhematopoietic toxici

6、ty in mice, and it can significantly suppress murine neuroblastoma tumor growth with littlesystemic toxicity 2.Animal Model: Adult male A/J mice, weighing 20 to 25 g with MNB cells 2Dosage: 1.5-2.5 mg/kgAdministration: Subcutaneous injection; 1.5-2.5 mg/kg; two 7-day periods interspersed by a 7-day

7、drugfree interval (minipump infusion)Result: Significantly suppressed murine neuroblastoma tumor growth.Prolongs the life span oftumor bearing mice.Did not suppress hematopoiesis when administered by steady stateinfusion 2.REFERENCES1. G V Madhavan, et al. Synthesis and antiviral evaluation of 6-sub

8、stituted aristeromycins: potential mechanism-based inhibitors of S-adenosylhomocysteine hydrolase. J Med Chem2. B Bostrom, et al. Inhibitory effect of adenosine dialdehyde on in situ murine neuroblastoma growth.Cancer Res. 1988 Nov1;48(21):5933-6.McePdfHeightCaution: Product has not been fully validated for medical applications.Fo