Guaiacol-2-Methoxyphenol-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEGuaiacolCat. No.: HY-N1380CAS No.: 90-05-1Synonyms: 2-Methoxyphenol分式: CHO分量: 124.14作靶点: COX; NF-B作通路: Immunology/Inflammation; NF-B储存式: Pure form -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100 mg

2、/mL (805.54 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 8.0554 mL 40.2771 mL 80.5542 mL5 mM 1.6111 mL 8.0554 mL 16.1108 mL10 mM 0.8055 mL 4.0277 mL 8.0554 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(

3、为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (20.14 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (20.14 mM); Clear solution1/2 Master of Small M

4、olecules 您边的抑制剂师www.MedChemE3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (20.14 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Guaiacol种从愈创树脂分离的酚类化合物，抑制 LPS 刺激的 COX-2 表达和 NF-B 激活 1。具有抗炎活性 1。IC50 & Target COX-2 NF-B体外研究 Guaiacol inhibits LPS-stimulated nuclear factor kappa B (NF-B) activation

5、and cyclooxygenase (COX)-2gene expression in cells of the RAW 264.7 murine macrophage cell line. Phenolic compounds such asPhenol, Eugenol, Guaiacol and Vanillin inhibit sheep vesicular gland prostaglandin cyclooxygenase, asindicated by their 50% inhibition concentrations, which decline in the follo

6、wing order: Phenol (1600 M) Vanillin (500 M) Guaiacol (72 M) Eugenol (12 M) 1.REFERENCES1. Murakami Y, et al. Re-evaluation of cyclooxygenase-2-inhibiting activity of vanillin and Guaiacol in macrophages stimulated withlipopolysaccharide. Anticancer Res. 2007 Mar-Apr;27(2):801-7.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400