Fosifloxuridine-nafalbenamide-NUC-3373-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEFosifloxuridinenafalbenamideCat.No.:HY-109115CASNo.:1332837-31-6Synonyms:NUC-3373分⼦式:C₂₉H₂₉FN₃O₉P分⼦量:613.53作⽤靶点:ThymidylateSynthase作⽤通路:Apoptosis储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:100mg/mL(162.99mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.6299mL8.1496mL16.2991mL5mM0.3260mL1.6299mL3.2598mL10mM0.1630mL0.8150mL1.6299mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%saline1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESolubility:≥2.5mg/mL(4.07mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.5mg/mL(4.07mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(4.07mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性Fosifloxuridinenafalbenamide(NUC-3373)属于嘧啶核苷酸类似物，⼀种胸腺嘧啶合酶(Thymidylatesynthase)抑制剂。Fosifloxuridinenafalbenamide具有抗癌活性。Fosifloxuridinenafalbenamide具有诱发宿主免疫反应和增强免疫治疗的潜⼒[1][2]。体外研究Fosifloxuridinenafalbenamideinducesthereleaseofdamage-associatedmolecularpatterns(DAMPs),withincreasedexpressionofcalreticulin(CRT)atthecellsurfaceandconcomitantlossofnuclearnuclearhighmobilitygroupboxprotein1(HMGB1)[1].体内研究Fosifloxuridinenafalbenamideexhibitsanti-canceractivityinHT-29nudemousexenograftmodels[2].REFERENCES[1].FionaG.McKissock,etal.Abstract1848:NUC-3373inducesERstressandthereleaseofdamageassociatedmolecularpatternsincolorectalcancercells.CancerResAugust152020(80)(16Supplement)1848.[2].EssamA.Ghazaly,etal.AbstractB46:NUC-3373:Anovelpyrimidinenucleotideanaloguethatovercomeskeycancerdrugresistancelimitingpatientsurvival.MolCancerTherDecember12015(14)(12Supplement2)B46.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuse