Cinnamaldehyde-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrarieswww.MedChemECinnamaldehydeCat.No.:HY-N0609CASNo.:104-55-2分⼦式:C₉H₈O分⼦量:132.16作⽤靶点:Bacterial;Apoptosis作⽤通路:Anti-infection;Apoptosis储存⽅式:-20°C,storedundernitrogen*Insolvent:-80°C,6months;-20°C,1month(storedunder

nitrogen)溶解性数据体外实验DMSO:100mg/mL(756.66mM;Needultrasonic)H2O:<0.1mg/mL(insoluble)MassSolvent1mg5mg10mgConcentration制备储备液1mM7.5666mL37.8329mL75.6659mL5mM1.5133mL7.5666mL15.1332mL10mM0.7567mL3.7833mL7.5666mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存⽅式和期限。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的⼯作液，建议您现⽤现配，当天使⽤；澄的储备液可以根据储存条件，适当保存；以下溶剂前的百分⽐指该溶剂在您配制终溶液中的体积占⽐)：1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(18.92mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:2.5mg/mL(18.92mM);Suspendedsolution;Needultrasonic3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(18.92mM);Clearsolution1/2MasterofSmallMolecules—您⾝边的抑制剂⼤师www.MedChemEBIOLOGICALACTIVITY⽣物活性Cinnamaldehyde⼀种主的⽣物活性化合物，从樟树叶中分离得到。Cinnamaldehyde⼀种细胞因⼦产⽣抑制剂。Cinnamaldehyde具有抗、抗氧化、抗炎的特性。体外研究CinnamaldehydeinhibitsROSreleaseandtheactivationofMAPKsaswellaspro-inflammatorycytokinesexpressionwithinTLRsactivatedculturedmonocytes/macrophages[1].CinnamaldehydeinducesapoptosisbymitochondrialpermeabilitytransitioninhumanpromyelocyticleukemiaHL-60cells,andinducesapoptosisinhumanhepatomacellsthroughactivationoftheproapoptoticBcl-2familyproteins[1].REFERENCES[1].ChaoLK,etal.Cinnamaldehydeinhibitspro-inflammatorycytokinessecretionfrommonocytes/macrophagesthroughsuppressionofintracellularsignaling.FoodChemToxicol.2008;46(1):220‐231.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-82