EHop-016 _Ras 抑制剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEEHop-016Cat. No.: HY-12810CAS No.: 1380432-32-5分式: CHNO分量: 430.55作靶点: Ras作通路: GPCR/G Protein储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 32 mg/mL (74.32 mM)* means soluble, but saturatio

2、n unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.3226 mL 11.6131 mL 23.2261 mL5 mM 0.4645 mL 2.3226 mL 4.6452 mL10 mM 0.2323 mL 1.1613 mL 2.3226 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，

3、适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.81 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (5.81 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您边的抑

4、制剂师www.MedChemESolubility: 2.5 mg/mL (5.81 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 EHop-016Rac GTPase效选择性抑制剂，在MDA-MB-435细胞中IC50值1.1uM。户使本产品发表的科研献 Mol Oncol. 2019 Jul 17. Appl Microbiol Biotechnol. 2018 Jul;102(14):5965-5975.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Mont

5、alvo-Ortiz BL, et al. Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase. J Biol Chem. 2012 Apr13;287(16):13228-38.2. Dharmawardhane S, et al. Development of EHop-016: a small molecule inhibitor of Rac. Enzymes. 2013;33 Pt A:117-46.3. Castillo-Pichardo L, et al. The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model. TranslOncol. 2014 Oct 24;7(5):546-55.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-379