青藏高原药用植物新药发现的潜在新资源

1、2021 Drug Discovery Forum China Taiyua n, ChinaNovember 13-16SCHEDULE OF EVENTSThursday, November 13, 20219:00 AM -10:00 PMRegistratio nDr. Zhao Xiaoda nFriday, November 14, 20218:00 AM-8:30 AMOpening CeremonyModerator: Dr . Zhang YongxiangIn troducti on of Atte nding Government Leaders and Honored

2、Guests byDr. Zha ng Yon gxia ngSecretary, Chin ese Pharmacological SocietyWelcome addressDr. Du Guan huaPreside nt, Chin ese Pharmacological SocietyRemarks by the Officials fromShanxi Un iversityShanxi Prov inceChin ese Mini stry of Scie nee and Tech no logyChin ese Associati on of Scie nee and Tech

3、 no logy8:30 AM-10:00 AMInvited Plenary LectureChair: Dr. Du GuanhuaScientific spirit revealed from disease management and prevention during the 2021 Wenchuan earthquake in Sichua n, China.Wang Yumin , Maj. Gen eral, Professor and Director , Office of Scie nee and Tech no logy, Chin ese Academy of M

4、ilitaryMedical Scie nee.Mitochondrial proteome plasticity of liver in response to obesity in mouse and to chronic poisoning by methylmercury in zebrafish.Francis Sluse, Professor, Chemistry Institute, Liege University , Belgium.Laboratory of Bioe nergetics and Cellular Physiology.Francis Sluse, Prof

5、essor, Chemistry Institute, Liege University , Belgium.Tea Break10:10 AM-11:20 AMSpecial Ple nary Lecture (I)Chair: Dr. Zhang YongxiangStrategy for new drug R&D from a view of new drug evaluati onShao Yin , Professor and Director , Divisio n III, Cen ter for Drug Evaluati on. State Food and Drug

6、 Admi nistrati on.Curre nt status and future direct ions for new drug R&D of Chin ese herbal medici ne.11:20 AM 12:00 AMZhang Lei , Professor and Director , Divisio n II, Cen ter for Drug Evaluati on, State Food and Drug Admi nistrati on.New Tech no logy and New Methodology Forum (I)Chair: Dr .

7、Zhang YongxiangStrategy and tech no logy used in efficacy study of new drug R&D.Li Hua , Investigator , Institute of Pharmacology and Toxicology, Chinese Academy of Military Medical Scienee.Applicati on of siRNA and micro RNA in drug discovery: an updateHe Min , Professor , Department of Pharmac

8、ology and Therapeutics, Nanchang University School of PharmacyLun ch, Poster2:00 PM-4:40 PMNew Tech no logy and New Methodology Forum (II)Chairs: Drs. Li Xueju n and Qin XuemeiEffect on fatigue of in tracellular metabolic waste aggregati on.Ji Yubi nAutophagy, tumor and n erve cell viability: a pote

9、 ntial new target for drug action?Qin Zhe nhongPlatform developme nt for active comp onent scree ning and efficacy study of drugs alleviat ing alcohol addicti on.Lia ng Jia nhuiUse of cell membra ne chromatography in drug discovery of Chin ese herbal medici ne complex system.Yua n Bin xia ngApplicat

10、ion of metabolomics in detecting metabolic changes of senescence-accelerated mouse (SAM) and elucidati on of pharmacological mecha ni sms.Jia ng Ni ngHybridization or bridging: new strategy for development of multi-target-directed anti-Alzheimer ' s drug using tacrinederivatives as prodrugs.Pi R

11、on gbiaoA study of cell death modes using atherosclerotic Guizhou min ipig model. Li Xin zhiCan prote in-prote in in teracti ons be used as drug targets?Xia Xia nminTea Break4:50 PM-6:06 PMPharmacology PhD Stude nt Forum (I)Chairs: Drs. Lv Guiyua n and Liu Jia nxunNew strategy for treatme nt and pre

12、ve nti on of n eurodege nerative disease: creati on and evaluati on of n eurovascular unit model.Liu RuiEffect on vascular en dothelial fun cti ons of Xyloketals isolated from a marine microorga ni sm.Che n Wen lia ngGen etic polymorphism of CYP2C19 and CYP2E1 among healthy Norther n Chin ese popula

13、tio n and liver tran spla nt recipie nts.Wang ShumeiGenomic DNA isolation and polymophism analysis of gut flora in rat.Sun Haife ngA prelim inary study of pan creatic islet beta-cell dysfu nction in MSG obese rat.Liu Shua inanOpening Recepti onSaturday, November 15, 20218:00 AM-11:55 AMPharmacology

14、PhD Stude nt Forum (II)Chairs: Drs. Zhou Wen xia and Ji Wen binInhibition of tumor cell migration by gensenoside 20 (R)_Rg3: possible involvement of the water channel AQP1.Guo HaoEffect of Kushe n formula decoct ion on TNF-alpha-i nduced eotax in expressi on in HaCaT cell li ne and dermal fibroblast

15、s.Peng ChengEnhanced bactericidal effect of various an tibiotics by co-applicati on with artes un ate tablet and study of un derly ing mecha ni sms.Li BinBerberi ne decreases blood glucose by in creas ing in suli n receptor expressi on.Zha ng HaoAngiogenesis promotion by catalpol using an animal mod

16、el of focal cerebral ischemia.Zhu Huife ngEffect on lear ning and memory in sen esce nce-accelerated mouse of JD-30, an active comp onent extracted from aChinese herbal formula: with a preliminary mechanism study.Hu ZengyaoCandida albicans RTA2 is a drug resistance target gene mediated by calcineuri

17、n signaling pathway.Jia Xi ngmi ngSource of in tracellular calcium in crease by 15-HETE in pul monary smooth muscle cells.Zheng Xiaodo ngTea BreakA study of finofibrate intervention to angiotensin II-induced inflammatory response in rat.Ji Yua nyua nUbiquitin ligase Hrd1 promotes degradation of muta

18、ted Z type alpha1-antitrypsin and cell survival ability.Wang Haipi ngApoptosis of huma n leukemia cell li ne HL-60 in duced by Brucea java nia oil emulsi on and the un derly ing mecha nismZhang HongA study of CpG DNA bin di ng site with extracellular doma in of TLR9 receptor .Di ng GuofuCon struct i

19、on of a cell model suitable for drug renal toxicity scree ning.Zha ng FengDevelopme nt of an in vivo hippocampal LTP record ing method and tech ni cal optimizati on of stereotactic localizati on.Huang YanSearch ing for Rho kin ase in hibitors by comb in atorial use of virtual scree ning and high thr

20、oughput scree ning.Gong LiliLun ch, Poster2:00 PM-2:35 PMSpecial Ple nary Lecture (II)Chair: Dr. Zhang YongxiangIntern ati onal sta ndard practices for new drug evaluati on and Chinay and challe nge ' s opport unitFu Lijie , Professor and Advisor , WHO GLP and Chemical Drug Safety Evaluati on2:4

21、0 PM - 6:00 PMScholar Salon: New Format and Strategy for Drug Discovery (I)Chair: Dr. Zhang YongxiangTarget discovery and validati on.Du Guan hua , Professor and Associated Director, I nstitute of Materia Matica, Chin ese Academy of Medical Scie neeApplicati on of fluoresce nt magn etic nano particl

22、es in drug scree ning.Zhang LuyongVirtual scree ning and drug discovery.Liu Aili ngHypoglycemic and -cell protective an drographolide-lipoic acid conjugate for diabetes treatme ntWang Yuqia ngResearch and developme nt of cardiovascular protect ion drugs of Class One New Drug Category.Zhu YichunDiscu

23、ssi on and Free Talk(max. 5 min for each speaker)Tea BreakMulti-target approach and drug discovery.Zhou Wen xiaAcid sen sitive ion cha nn el (ASIC): a new drug target.Chen Jia nguoApplicati on of new imagi ng tech nique in pig model of pul monary embolism.Qia n BaichuAmino acid content in medial pre

24、fr on tal cortex of mouse with methamfetam in e-i nduced con diti oned place prefere nee.Yang Jin gyuDiscussi on and Free Talk(max. 5 min for each speaker)DinnerPM9:10 PMScholar Salon: New Format and Strategy for Drug Discovery (II)Chair: Dr. Du Gua nhuaStrategy and methods used in toxicity study du

25、ri ng new drug discovery stage.Liao Min gya ngA brief in troduct ion of new tech niq ues used in peri natal drug R&D and safety evaluati on Xu ZhiceCon struct ion of a function-coupled biological n etwork based on psoriasis-related toxicology and drug resista nee gene chip expressi on and an aly

26、sis of the n etwork regulati on.Hu JinhongImpoveme nt of ELISA-based activity detect ion assay.Jin SiDiscussi on and Free Talk(max. 5 min for each speaker)-12:00 AMSun day, November 16, 2021Scholar Salon: New Format and Strategy for Drug Discovery (III)Chair: Dr. Du GuanhuaAccelerati ng moder ni zat

27、i on and globalizati on of Chin ese herbal medici ne: where lies the breakthrough point? Zhang Jun tia nHerbolome and new drug discovery.Lia ng Xin miaoWays of thinking and methods used in new drug discovery of Chin ese herbal formula.Zha ng Yon gxia ngTarget scree nin g-based new drug discovery.Liu

28、 Jia nxunWhat do we learn for moder n pharmacology and life scie nee research from Traditi onal Chin ese Medici ne and its theory?Chen Yon ggua nNew drug discovery of high-efficie nt, unique Chin ese herbal medici ne by compari ng blood pressure-loweri ng effect of an tihyperte nsive age nts.Lv Guiy

29、a n Discussi on and Free Talk(max. 5 min for each speaker)Tea BreakImpact on drug research of theory and tech nique of moder n biology and systems biology.Li Xueju nSome opinions on pharmacok in etics study of Chin ese herbal formula.Zhu XiaoxinNew theory and methods for mecha ni sm-based pharmacok in etics prescripti on of Chin ese herbal formula.Hao Haip inApplication of visualization techniqu