溃疡性结肠炎的共识意见

1、Consensus Stange EF, Travis SP, Vermeire S, Reinisch W, Geboes K, Barakauskiene A, et al. European evidence-based Consensus on the diagnosis and management of ulcerative colitis: definitions and diagnosis. J Crohns Colitis 2008;2:123. Van Assche G，Dignass A，Panes J，et a1The second European evidence-

2、based Consensus on the diagnosis and management of ulcerative colitis：Definitions and diagnosisJ Crohns Colitis，20104：7 27 Mowat C, Cole A, Windsor A, Ahmad T, Arnott I, Driscoll R, et al. Guidelines for the management of inflammatory bowel disease in adults. Gut 2011;60:571607. Turner D, Levine A,

3、Escher JC, Griffiths AM, Russell RK, Dignass A, et al. Management of pediatric ulcerative colitis: a joint ECCO and ESPGHAN evidence-based consensus guidelines. J Pediatr Gastroenterol Nutr 2012. Turner D, Travis SP, Griffiths AM, Ruemmele FM, Levine A, Benchimol EI, et al. Consensus for managing ac

4、ute severe ulcerative colitis in children: a systematic review and joint statement from ECCO, ESPGHAN, and the Porto IBD Working Group of ESPGHAN. Am J Gastroenterol 2011;106:57488.Management consensus of inflammatory bowel disease forthe AsiaPacific region 2006Abstract: At the present there are no

5、large-scale epidemiologic data on inflammatory bowel disease (IBD) in the AsiaPacific region, but several studies have shown an increased incidence and prevalence of IBD in this region. Compared to the West, there appears to exist a time lag phenomenon. With regard to the two main forms of IBD, ulce

6、rative colitis (UC) is more prevalent than Crohns disease (CD). In addition to geographic differences, ethnic differences have been observed in the multiracial Asian countries. Moreover, the genetic backgrounds are different in the Asian compared to Western patients. For instance, NOD2/CARD15 varian

7、ts have not been found in Asian CD patients.In general, the clinical course of IBD seems to be less severe in the AsiaPacific region than in Western countries.Diagnosis of IBD in this region poses special problems. The lack of a gold standard for the diagnosis of IBD, and the existence of a variety

8、of infectious enterocolitis with similar manifestations to those of IBD make the differential diagnosis particularly difficult. So far,Western diagnostic criteria have been introduced for the diagnosis of IBD. A stepwise approach to exclude non-IBD enterocolitis also must be introduced, and a defini

9、te diagnosis must include typical histological features. In some patients, follow up and therapeutic trials might be necessary to obtain a definitive diagnosis. A better understanding of the pathogenesis of IBD will allow the development of better diagnostic markers. The management of IBD also poses

10、 some special problems in the AsiaPacific Region. There is often a delay in using proper medications for IBD, and alternative local remedies are still widely used. With a combination ofWestern guidelines and regional experiences, similar principles can be used for induction and maintenance of remiss

11、ion.A stepwise selection of medications is advocated depending on the extent, activity and severity of the disease. Comprehensive and individualized approaches are suggested for different IBD patients. Deeper understanding of disease pathogenesis and the unique characteristics of IBD in the AsiaPaci

12、fic region, combined with reasonable and practical guidelines for drug management and the future use of biological agents would improve the therapeutic outlook of IBD in this region.The Asia-Pacific consensus on ulcerative colitis 2010European evidence-based consensus on the diagnosis/management of

13、ulcerative colitis 2008 This document sets out the current European Consensus on the diagnosis andmanagement of UC, reached by the European Crohns and Colitis Organisation (ECCO) at a meeting held in Berlin on 20th October 2006. ECCO is a forum for specialists in inflammatory bowel disease from 23 E

14、uropean countries. Like the initial Consensus on the management of Crohns disease, the current Consensus is grouped into three parts: definitions and diagnosis; current management; and management of special situations. This first section concerns aims, methods and definitions of the Consensus, as we

15、ll as classification, diagnosis, imaging and pathology of UC. The second section on current management includes treatment of active disease, maintenance ofmedically-induced remission and surgery of UC. The third section on special situations includes pouch disorders, cancer surveillance, pregnancy,

16、paediatrics, psychosomatics, extra-intestinal manifestations and alternative therapy.2nd European evidence-based consensus on the diagnosis/management of ulcerative colitis 2012 This document updates the previous European Consensus on the diagnosis and management of UC, and was finalised by the Euro

17、pean Crohns and Colitis Organisation (ECCO) at a meeting held in Dublin in February 2011. ECCO is a forum for specialists in inflammatory bowel disease from 31 European countries. Like the initial Consensus on the diagnosis and management of ulcerative colitis,68 this updated Consensus is grouped in

18、to three parts: definitions and diagnosis; current management; and management of special situations. Previously included chapters on pregnancy and pediatrics are no longer included in this guideline, as specific ECCO Consensus Guidelines on Reproduction and Pregnancy and Pediatric UC (together with

19、ESPGHAN) cover these topics extensively.Ulcerative colitis in China: Retrospective analysis of 3100hospitalized patientsBackground & Aims: This retrospective study analyzed the clinical characteristics of hospitalized patients with ulcerative colitis (UC) in China.Methods: A total of 3100 hospit

20、alized patients with UC admitted to 23 hospitals in China from 1990 to 2003 were retrospectively investigated and their clinical characteristics were analyzed.Results: A male/female ratio of 1.34/1.00 was found in the 3100 patients, who had an average age of 44 15.1 years at diagnosis. Of the patien

21、ts, 2972 (95.9%) had active UC. Active UC was mild in 35.4% of the 2972 patients, moderate in 42.9% and severe in 21.7%. Of the 2726 patients with a description of their lesion extent, 14.8% had proctitis, 26.4% had proctosigmoiditis, 25.0% had left-sided colitis, 6.3% had extensive colitis, 25.8% h

22、ad pancolitis and 1.7% had regional colitis. The predominant complaints of the patients with UC were bloody diarrhea (48.2%), abdominal pain (67.3%) and mucus stools (58.4%). Among these patients, 13.6% had extraintestinal manifestations and 9.6% had related complications. A differential diagnosis w

23、as difficult to make, as there were 19 varieties of the disease; infectious enterocolitis had a misdiagnosis rate of 22.9% before admission. The main medications for UC in China were aminosalicylates (66.8%) and steroids (42.8%). Only 94 (3%) of the patients required colectomy and only 19 (0.6%) died of UC.Conclusions: Compared with UC in Western countries, ulcerative colitis in China has some differences in clinical characteristics. The