Avanafil-d4-TA1790-d-sub-4-sub-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEAvanafil-d4Cat.No.:HY-18252S2CASNo.:2012598-68-2Synonyms:TA1790-d4分⼦式:C₂₃H₂₂D₄ClN₇O₃分⼦量:487.98作⽤靶点:NOSynthase;EndogenousMetabolite;Phosphodiesterase(PDE);Isotope-LabeledCompounds作⽤通路:Immunology/Inflammation;MetabolicEnzyme/Protease;Others储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Avanafil-d4(TA1790-d4)氘代标记的Avanafil(HY-18252)。体外研究Stableorradioisotope-labeledcompoundsallowprecisetrackingandquantificationofindividualatomsinmetabolicpathways.Stableisotopesgenerallydonotchangemolecularpropertiesbutmayslightlyaffectmetabolickinetics;radioactiveisotopesmayinterferewithcells.Markerscandistinguishendogenousandexogenousmetabolites,reducefalsepositives,andarebeneficialtoquantificationandreconstructionofmetabolicpathways[2].Incellcultureorenzymaticreactions,theuseofisotopemarkerscanpreciselycontroltheconcentrationandexposuretime,makingiteasytostudymetabolicreactionsandenzymeactivities.Throughstableisotopeanalyticalmetabolomics(SIRM),cellularmetabolicnetworkscanbestudied,keymetabolicnodesandregulatorymechanismscanbeidentified,andtargetscanbeprovidedforcompounddevelopment.Isotope-labeledcompoundscanbeusedincompetitionbindingexperimentstoevaluatetheaffinityandbindingkineticsofcompoundstoreceptorstohelpoptimizedesign.Stableisotopelabelsareusedasinternalstandardsinmassspectrometryanalysistoimproveanalysisaccuracyandreproducibilityandreducematrixeffectinterference[3].体内研究Isotopiclabelscannon-invasivelytrackthedistribution,transformationandclearanceofcompoundsandtheirmetabolitesinthebodythroughtechniquessuchasmassspectrometry(MS)andnuclearmagneticresonance(NMR),whichisbeneficialtothestudyofpharmacometabolickinetics(ADME).Isotopelabelingcanrevealspecificstepsinmetabolicpathways.Usingcompoundswithstableisotopelabels1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEatspecificlocationsdirectlyinhumansoranimalmodelscanalsohelpverifydrugmechanismsandevaluateunexpectedsideeffects,improvingtheaccuracyandefficiencyofclinicalresearch[3].REFERENCES[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-216.[2].SmithKA,etal.Soilandenvironmentalanalysis[M].MarcelDekkerIncorporated,2000.[3].FanTWM,etal.Stableisotope-resolvedmetabolomicsandapplicationsfordrugdevelopment[J].Pharmacology&therapeutics,2012,133(3):366-391.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapp