Mezigdomide-CC-92480-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEMezigdomideCat.No.:HY-129395CASNo.:2259648-80-9Synonyms:CC-92480分⼦式:C₃₂H₃₀FN₅O₄分⼦量:567.61作⽤靶点:E1/E2/E3Enzyme;MolecularGlues;Apoptosis作⽤通路:MetabolicEnzyme/Protease;PROTAC;Apoptosis储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:5mg/mL(8.81mM;ultrasonicandwarmingandheatto60°C)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.7618mL8.8089mL17.6177mL5mM0.3524mL1.7618mL3.5235mL10mM---------请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性Mezigdomide(CC-92480)⼀种cereblonE3泛素连接酶调节药物(CELMoD)，以分⼦胶的⽅式作⽤。Mezigdomide与cereblon有较强的亲和⼒，具有抗⾻髓瘤活性。体外研究Mezigdomideisthesecondcereblonmodulator.Mezigdomide-inducedlossofAiolosandIkarosincultures1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEofPBMCsresultedintheactivationofTcellsandincreasedproductionofIL-2andIFN-γ.MezigdomideiseffectiveinCC-5013,CC-4047,andCC-220-resistantcelllines.Itexertssingle-agentinductionofapoptosisandexhibitsremarkablesynergywithNSC34521[1].REFERENCES[1].NookaAK,etal.MechanismofActionandNovelIMiD-BasedCompoundsandCombinationsinMultipleMyeloma.CancerJ.2019Jan/Feb;25(1):19-31.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax