OUL35-NSC39047-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEOUL35Cat.No.:HY-123512CASNo.:6336-34-1Synonyms:NSC39047分⼦式:C₁₄H₁₂N₂O₃分⼦量:256.26作⽤靶点:PARP作⽤通路:CellCycle/DNADamage;Epigenetics储存⽅式:4°C,protectfromlight*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)溶解性数据体外实验DMSO:83.33mg/mL(325.18mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM3.9023mL19.5114mL39.0229mL5mM0.7805mL3.9023mL7.8046mL10mM0.3902mL1.9511mL3.9023mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(protectfromlight)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.08mg/mL(8.12mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE2.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(8.12mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性OUL35(NSC39047)选择性的ARTD10(PARP-10)抑制剂，其IC50值为329nM。IC50&TargetARTD10/PARP10329nM(IC50)体外研究OUL35rescuesHeLacellsfromARTD10-inducedcelldeathandsensitizescellstoDNAdamage.OUL35(3μM)bindstoendogenousARTD10inU2OScells[1].OUL35alsoinhibitsARTD8(23.4μM),ARTD4(22.6μM),andARTD15(4.17μM)butwithmodestpotency[1].OUL35makeshydrogenbondstotheamideandcarbonylofGly888andtotheside-chainhydroxylofSer927.OUL35stacksbetweenTyr919andTyr932,like3ABinthecrystalstructure[1].REFERENCES[1].HarikanthVenkannagari,etal.Small-MoleculeChemicalProbeRescuesCellsfromMono-ADP-RibosyltransferaseARTD10/PARP10-InducedApoptosisandSensitizesCancerCellstoDNADamage.CellChemBiol.2016Oct20;23(10):1251-1260.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-8