TIE-2-VEGFR-2-kinase-IN-1-DataSheet-生命科学试剂-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrarieswww.MedChemETIE-2/VEGFR-2kinase-IN-1Cat.No.:HY-112294CASNo.:453590-24-4分⼦式:C₁₃H₁₁N₃O₂分⼦量:241.25作⽤靶点:VEGFR作⽤通路:ProteinTyrosineKinase/RTK储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:5mg/mL(20.73mM;ultrasonicandwarmingandheatto80°C)MassSolvent1mg5mg10mgConcentration制备储备液1mM4.1451mL20.7254mL41.4508mL5mM0.8290mL4.1451mL8.2902mL10mM0.4145mL2.0725mL4.1451mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存⽅式和期限。BIOLOGICALACTIVITY⽣物活性TIE-2/VEGFR-2kinase-IN-1⽤于合成TIE-2或者VEGFR-2抑制剂，从专利WO2003022852中获得，例14。TIE-2/VEGFR-2kinase-IN-1⽤于研究不适当的⾎管⽣成相关疾病。体外研究Angiopoieten1isaligandfortheendotheiium-specificreceptortyrosinekinase,TIE-2isanovelangiogenicfactor[1].InhibitionofTIE-2isexpectedtoservetodisruptremodelingandmaturationofnewvasculatureinitiatedbyangiogenesistherebydisruptingtheangiogenicprocess.InhibitionatthekinasedomainbindingsiteofVEGFR-2wouldblockphosphorylationoftyrosineresiduesandservetodisruptinitiationof1/2MasterofSmallMolecules—您⾝边的抑制剂⼤师www.MedChemEangiogenesis.REFERENCES[1].JerryLeroyAdams,etal.Furo-andthienopyrimidinederivativesasangiogenesisinhibitors.PatentWO2003022852.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax: