Ambroxol-hydrochloride-NA-872-hydrochloride-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAmbroxol hydrochlorideCat. No.: HY-B1039ACAS No.: 23828-92-4Synonyms: NA-872 hydrochloride分式: CHBrClNO分量: 414.56作靶点: Glucosidase; Autophagy作通路: Metabolic Enzyme/Protease; Autophagy储存式: 4C, sealed storage, away from moisture* In

2、solvent : -80C, 6 months; -20C, 1 month (sealedstorage, away from moisture)溶解性数据体外实验 H2O : 8.33 mg/mL (20.09 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.4122 mL 12.0610 mL 24.1220 mL5 mM 0.4824 mL 2.4122 mL 4.8244 mL10 mM 0.2412 mL 1.2061 mL 2.4122 mL请根据产品在不同溶剂中的溶解度，选择合适

3、的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Ambroxol hydrochloride (NA-872 hydrochloride)前药溴的活性代谢产物，具有强效祛痰作。Ambroxol hydrochloride种葡糖脑苷脂酶 (GCase) 伴侣，可增加葡糖脑苷脂酶的活性。Ambroxolhydrochloride 可诱导肺噬，并有于帕森病和神经性谢病研究的潜。体内研究Ambroxol hydrochloride (NA-872 hydrochloride; 1, 3, 4, 5 mM for 12 consecutive days in

4、 drinking water)results in increased brain glucocerebrosidase activity in wild-type mice, transgenic mice expressing theheterozygous L444P mutation in the murine glucocerebrosidase 1 gene, and transgenic mice overexpressing1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEhuman -synuclein 2.REFERENCE

5、S1. Vojo Deretic, et al. Enhancement of lung levels of antibiotics by ambroxol and bromhexine. Expert Opin Drug Metab Toxicol. 2019Mar;15(3):213-218.2. Anna Migdalska-Richards, et al. Ambroxol effects in glucocerebrosidase and -synuclein transgenic mice. Ann Neurol. 2016Nov;80(5):766-775.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021