Embase中的生命科学信息查询PPT课件

1、Embase中的生命科学信息查询俞靓 Elsevier生命科学产品客户顾问 | 2 Embase简介Embase中的内容Embase中的索引与应用 Embase中的检索Embase中的基本检索Embase中的生物医学文献检索与分析Embase中的模块化检索（循证医学，药物警戒） Embase检索小结提纲 | 3 Embase是领先的生物医学文献数据库，具有最全面的期刊和会议报道，生命科学索引体系和强大的搜索引擎，能帮助科研人员从错综复杂的全文中快速定位最关关键的内容。什么是EmbasePharmaA&GMedicalDevices | 4Embase中的内容更多的非英文文献的覆盖Emb

2、ase8000 journals / 35 Million records!2,750 Journals not available on MEDLINE药物，疾病，器械的深度索引，索引词表是Medline的2倍以上基于摘要，深度索引词的独特搜索引擎允许保存、共享和编辑复杂搜索策略2009年以来的超过9300个会议，超过300万条会议记录 | 5Embase中拥有更多的国际内容覆盖EU, 51%NA, 31%AP, 11%ROW, 6%Embase content coverage050100150200250300IndiaJapanChinaAustraliaSouth KoreaTaiw

3、anMalaysiaThailandAPAC0100200300400500600GermanyNetherlandsSwitzerlandItalyFranceSpainPolandTurkeyRussian FederationIrelandCzech RepublicEuropeCount of Covered in EmbaseCount of Covered in MEDLINE020406080100120140160United ArabIranTurkeyBrazilRussian FederationMexicoSouth AfricaEgyptArgentinaEMLA |

4、 6 Embase简介Embase中的内容Embase中的索引与应用 Embase中的检索Embase中的基本检索Embase中的生物医学文献检索与分析Embase中的模块化检索（循证医学，药物警戒） Embase检索小结提纲生物医药检索中的一种常见的漏检类型生物医药检索中的一种常见的漏检类型这是一篇关于联合使用钙离子拮抗剂，受体阻滞剂，用于降压的一篇报道，摘要中只出现了4个药物，阿替洛尔、硝苯地平、拉西地平及舍曲林全文中的内容全文中的内容我们通过阅读全文，发现还有第5种药物出现，Fluoxetinee。文献检索中，仅仅通过检索题录，摘要，远远不能满足循证方面的要求。Medline中的记录中的

5、记录Medline中没有提炼，所以当用Fluoxetinee进行检索的时候，会漏掉Embase中的记录中的记录 | 11Embase的全文深度索引Embase内容预览提炼内容可用于标记和检索依据Emtree将索引词标准化从全文中抽提最相关内容 | 12深度挖掘后的索引标准化TitleAbstractDrug termsDisease termsOther terms | 13标准化后的逻辑关系搭建三层索引体系的搭建文献中的词条全部通过Emtree做过标准化处理 | 14 Embase简介Embase中的内容Embase中的索引与应用 Embase中的检索Embase中的基本检索Embase中的

6、生物医学文献检索与分析Embase中的模块化检索（循证医学，药物警戒） Embase检索小结提纲 15Embase登录界面基本检索模块基本检索模块快速检索PICOPV Wizard高级检索药物检索疾病检索器械检索文献检索作者检索浏览模块浏览模块Emtree检索期刊检索 利用布尔运算符可以将多个词语进行连接and， or，notnear/n, next/n16Embase中的词语连结NEAR，不考虑前后两个词语的顺序NEXT，需要考虑顺序 | 17 Emtree是关于生物医药和生命科学的控制词表 利用Emtree可以确定最适合的检索词 帮助创建最适当的检索式 树结构包含15个层次。每个层次代表一

7、个大类学科（解剖学、生物化学、药物、疾病、医疗技术与设备，病人组，等）。EmtreeEmbase的核心索引体系 | 18 Embase简介Embase中的内容Embase中的与索引与应用 Embase中的检索Embase中的基本检索Embase中的生物医学文献检索与分析Embase中的模块化检索（循证医学，药物警戒） Embase检索小结提纲 检索和CDK4/6靶点相关的文献19Case Study 1 生物医药类文献的查询Tips：1. 选择检索范围2. 涉及多个检索项的时候，需要考虑之间的关系3. 直接输入CDK，系统可以给出Emtree中相关词汇，20获得结果Tips：可以利用这里更多的

8、工具，获得更加精准的文献。21Maping工具的使用Embase mapping optionsMap to preferred term in Emtree用Emtree中匹配的词去检索Index Term部分Search also as free text in all fields用输入的词检索所有字段Explode using narrower Emtree terms用Emtree中匹配的词以及这些词的下位词检索Index Term部分Search as broadly as possibleEmtree的词，下位词，同义词，Free Text检索所有字段Limit to terms

9、 indexed in articles as “major focus”:将检索词锁定在Major Focus部分Tips：通过不同的匹配度进行结果的扩展或者精炼22Major Focus结果可以通过Filter工具进一步对结果进行筛选Tips：Embase将所有的检索历史列举在接口，可以随时查看，方便结果集之间的逻辑关系23Filter工具的使用Tips：1.Embase能帮助检索到很多Medline检索不到的文献2.Study Tpye分析，帮助获得文献涉及的最直接的研究方向。24更多的Filter工具DiseasesTips：1.Disease分析，帮助从疾病领域出发，对文献进行筛选，

10、获得这个靶点可能从事的疾病的研究2.在Subheading中可以获得更加细节性的内容，包括药物治疗，不良反应等，3.一些在研/上市的药物名称也可以通过这种方式获得。25更多的Filter工具DrugsTips：1.进一步的Durg分析可以从药物的角度帮助获得文献中涉及到的药物不良反应，药物联用，药物比较等细节性的内容2.所有的检索，筛选历史全部位于History的部分，用于掌握结果的检索逻辑。 | 26其中一条记录可以打开药物和疾病的词条查看文献中的关键内容 | 27药物方面词条文献中报道的不良反应：文献中报道的不良反应：腹泻、疲劳、高转氨酶血症、白细胞减少、粘膜炎症、中性粒细胞减少、皮疹文献

11、中报道的联用信息：文献中报道的联用信息：阿那曲唑、联苯双酯、氟维司琼、GEDTA、Gelelelin、来曲唑、培妥珠单抗、曲妥珠单抗文献中报道的药物对比信息：文献中报道的药物对比信息：环磷酰胺、多西他赛、表阿霉素、氟尿嘧啶、紫杉醇、安慰剂文献中报道的药物治疗信息：文献中报道的药物治疗信息：乳腺癌与转移性乳腺癌 | 28 获得2017 ASCO会议内容Case Study 2 会议的查询 | 29检索的结果 | 30 Embase简介Embase中的内容Embase中的与索引与应用 Embase中的检索Embase中的基本检索Embase中的生物医学文献检索与分析Embase中的模块化检索（循证

12、医学，药物警戒） Embase检索小结提纲药物警戒检索的构成药物警戒检索的构成drug names adverse drug reaction 11.7Mspecial conditions6.8Mhuman limit19.9Mdrug subheadings药物相关副标题药物相关副标题paracetamol/drug toxicity,drug interaction,adverse drug reaction药物名称或者药物的不同表述形式药物名称或者药物的不同表述形式paracetamol:de OR 4 acetamidophenol:tn,ab,ti OR 4 acetaminoph

13、enol:tn,ab,ti OR 4 acetylaminophenol:tn,ab,ti OR 4 hydroxyacetanilide:tn,ab,ti OR 4 hydroxyacetanilide:tn,ab,ti OR abenol:tn,ab,ti OR acamol:tn,ab,ti OR acamoli forte suppositories for kids:tn,ab,ti OR acenol:tn,ab,ti OR acephen:tn,ab,ti OR acet suppositories:tn,ab,ti OR acetalgin:tn,ab,ti OR acetam

14、ino phenol:tn,ab,ti OR acetaminophen:tn,ab,ti OR acetaminophene:tn,ab,ti OR acetaminophenol:tn,ab,ti OR acetamol:tn,ab,ti OR acetomenophen:tn,ab,ti OR acetylaminophenol:tn,ab,ti OR adorem:tn,ab,ti OR afebrin:tn,ab,ti OR 与药物不良反应相关的词与药物不良反应相关的词paracetamol-induced:ab,ti OR (adverse drug reaction/exp OR

15、 adverse drug reaction:lnk OR adverse:de,ab,ti OR (side OR undesirable OR unwanted) NEXT/2 (effect* OR reaction* OR event* OR outcome*):de,ab,ti OR side effect/lnk OR side effect/exp OR complication/lnk OR complication/exp OR complication*:de,ab,ti OR worsening:de,ab,ti OR case report*:de,ab,ti OR p

16、harmacovigilance:de,ab,ti OR postmarketing surveillance/exp OR drug interaction:lnk OR drug interaction/exp OR toxicity/exp OR drug toxicity:lnk OR toxic*:de,ab,ti OR intox*:de,ab,ti OR safety:de,ab,ti OR poison*:de,ab,ti OR pharmacotox*:de,ab,ti OR neurotox*:de,ab,ti OR cardiotox*:de,ab,ti OR nephr

17、otox*:de,ab,ti OR hepatotox*:de,ab,ti OR immunotox*:de,ab,ti OR immunocytotox*:de,ab,ti OR cytotox*:de,ab,ti OR carcinogen*:de,ab,ti OR cancerogen*:de,ab,ti OR mutagen*:de,ab,ti OR terato*:de,ab,ti OR fatal outcome/exp OR death/exp OR death*:de,ab,ti OR suicide/exp OR suicid*:de,ab,ti OR mortal*:de,

18、ab,ti OR fatal*:de,ab,ti OR risk/exp OR nocebo:de,ab,ti OR lethal concentration/exp OR iatrogenic disease/exp OR fertility/exp OR substance-related disorders/exp OR chemically induced:de,ab,ti OR morbidity:de,ab,ti OR congenital disorder:de,ab,ti OR infertility/exp OR injury/exp)特殊的一些条件特殊的一些条件pregna

19、ncy/exp OR pregnant*:de,ab,ti OR pregnanc*:de,ab,ti OR pregnancy complication/exp OR pregnancy disorder/exp OR abortion/exp OR abortion:de,ab,ti OR lactation/exp OR breast feeding:de,ab,ti OR breastfeeding:de,ab,ti OR breast milk:de,ab,ti OR reproduction/de OR fetus/de OR embryo/de OR prenatal:de,ab

20、,ti OR perinatal:de,ab,ti OR newborn:de,ab,ti OR parameters concerning the fetus, newborn and pregnancy/exp OR aged/exp OR elderly:de,ti,ab OR geriatric*:ti,ab OR (environmental OR occupational) NEXT/1 exposure*):de,ab,ti OR compassionate use:de,ab,ti OR (named NEXT/1 (use OR patient*):ab,ti OR inap

21、propriate prescri*:de,ab,ti OR drug metabolism/exp OR organ dysfunction:de,ab,ti OR organ failure:de,ab,ti OR hypersensitivit*:de,ab,ti OR allerg*:de,ab,ti OR counterfeit:de,ab,ti OR falsified drug:de,ab,ti OR (unavailab* NEAR/2 drug):de,ab,ti OR drug resistance/exp OR drug resistance:de,ab,ti OR wi

22、thdrawal syndrome/de OR (drug* NEAR/3 (withdrawal OR toleran* OR interact* OR exposure* OR induc* OR resist* OR ineff* OR nonrespon* OR unrespon*):de,ab,ti OR drug tolerance/exp OR (drug* OR treatment) NEXT/1 (failure* OR contraindication*):de,ab,ti OR medication error/exp OR (near NEXT/1 miss*):ab,

23、ti OR ineff*:ti OR nonrespon*:ti OR unrespon*:ti OR (lack OR no OR non OR not) NEXT/2 (eff* OR respon*):ab,ti OR device failure:de,ab,ti OR manufacturing near/3 (error or fault or mistake or failure or contamination or impurity) OR patient compliance/exp OR overdos*:de,ab,ti OR drug abuse/exp OR abu

24、s*:de,ab,ti OR misus*:de,ab,ti OR off label:de,ab,ti OR unlicensed:de,ab,ti人的设定人的设定(human/exp OR human OR m?n OR wom?n OR child OR boy OR girl)这部分往往就是药物警戒需要这部分往往就是药物警戒需要看的文献看的文献Designed to produce 100% recall against the gold set (in appendix).Build the full search strategy with structured guidancep

25、aracetamol/drug toxicity,drug interaction,adverse drug reaction OR paracetamol-induced:de,ab,ti OR (paracetamol:de OR 4 acetamidophenol:tn,ab,ti OR 4 acetaminophenol:tn,ab,ti OR 4 acetylaminophenol:tn,ab,ti OR 4 hydroxyacetanilide:tn,ab,ti OR 4 hydroxyacetanilide:tn,ab,ti OR abenol:tn,ab,ti OR acamo

26、l:tn,ab,ti OR acamoli forte suppositories for kids:tn,ab,ti OR acenol:tn,ab,ti OR acephen:tn,ab,ti OR acet suppositories:tn,ab,ti OR acetalgin:tn,ab,ti OR acetamino phenol:tn,ab,ti OR acetaminophen:tn,ab,ti OR acetaminophene:tn,ab,ti OR acetaminophenol:tn,ab,ti OR acetamol:tn,ab,ti OR acetomenophen:

27、tn,ab,ti OR acetylaminophenol:tn,ab,ti OR adorem:tn,ab,ti OR afebrin:tn,ab,ti OR algiafin:tn,ab,ti OR algotropyl:tn,ab,ti OR alphagesic:tn,ab,ti OR alvedon:tn,ab,ti OR amadil:tn,ab,ti OR anacin 3:tn,ab,ti OR anaflon:tn,ab,ti OR analgiser:tn,ab,ti OR apamide:tn,ab,ti OR apap:tn,ab,ti OR apirex:tn,ab,

28、ti OR apotel:tn,ab,ti OR arthralgen:tn,ab,ti OR atamel:tn,ab,ti OR ben-u-ron:tn,ab,ti OR benuron:tn,ab,ti OR biogesic:tn,ab,ti OR biogesic suspension:tn,ab,ti OR bodrex:tn,ab,ti OR calapol:tn,ab,ti OR calodol:tn,ab,ti OR calonal:tn,ab,ti OR calpol:tn,ab,ti OR causalon:tn,ab,ti OR cemol:tn,ab,ti OR c

29、hristamol:tn,ab,ti OR claradol:tn,ab,ti OR clocephen:tn,ab,ti OR cp 500:tn,ab,ti OR cp500:tn,ab,ti OR dafalgan:tn,ab,ti OR daga:tn,ab,ti OR datril:tn,ab,ti OR depon:tn,ab,ti OR depyretin:tn,ab,ti OR dirox:tn,ab,ti OR dismifen:tn,ab,ti OR disprol:tn,ab,ti OR dolal:tn,ab,ti OR dolex:tn,ab,ti OR dolex

30、500:tn,ab,ti OR doliprane:tn,ab,ti OR dolitabs:tn,ab,ti OR dolofen:tn,ab,ti OR dolomol:tn,ab,ti OR dolorol:tn,ab,ti OR dolotemp:tn,ab,ti OR dolprone:tn,ab,ti OR doltem:tn,ab,ti OR drilan:tn,ab,ti OR dristan af:tn,ab,ti OR duorol:tn,ab,ti OR dymadon:tn,ab,ti OR efferalgan:tn,ab,ti OR efferalgan 500:t

31、n,ab,ti OR efferalganodis:tn,ab,ti OR efferelgan:tn,ab,ti OR enelfa:tn,ab,ti OR eneril:tn,ab,ti OR eraldor:tn,ab,ti OR expandol:tn,ab,ti OR febrilix:tn,ab,ti OR fendon:tn,ab,ti OR fervex:tn,ab,ti OR fibrinol:tn,ab,ti OR fortolin:tn,ab,ti OR gelocatil:tn,ab,ti OR geluprane 500:tn,ab,ti OR gunaceta:tn

32、,ab,ti OR headache strength allerest:tn,ab,ti OR hedex:tn,ab,ti OR infants feverall:tn,ab,ti OR injectapap:tn,ab,ti OR janupap:tn,ab,ti OR kamolas:tn,ab,ti OR kyofen:tn,ab,ti OR lemgrip:tn,ab,ti OR letamol:tn,ab,ti OR liquiprin:tn,ab,ti OR lotemp:tn,ab,ti OR lyteca:tn,ab,ti OR malidens:tn,ab,ti OR m

33、edamol:tn,ab,ti OR meforagesic:tn,ab,ti OR metagesic:tn,ab,ti OR metalid:tn,ab,ti OR mexalen:tn,ab,ti OR milidon 500:tn,ab,ti OR minopan:tn,ab,ti OR mypara:tn,ab,ti OR n acetyl 4 aminophenol:tn,ab,ti OR n acetyl para aminophenol:tn,ab,ti OR n-acetyl-p-aminophenol:tn,ab,ti OR nalgesik:tn,ab,ti OR nap

34、amol:tn,ab,ti OR napap:tn,ab,ti OR naprex:tn,ab,ti OR nektol 500:tn,ab,ti OR neocitran:tn,ab,ti OR neodalmin:tn,ab,ti OR neopap:tn,ab,ti OR nevral:tn,ab,ti OR nilapur:tn,ab,ti OR nobedon:tn,ab,ti OR nysacetol:tn,ab,ti OR ofirmev:tn,ab,ti OR pacemol:tn,ab,ti OR pacimol:tn,ab,ti OR pamal:tn,ab,ti OR p

35、amol:tn,ab,ti OR panadol:tn,ab,ti OR panadol actifast:tn,ab,ti OR panadol soluble:tn,ab,ti OR panamax:tn,ab,ti OR panasorb:tn,ab,ti OR panodil:tn,ab,ti OR para acetamidophenol:tn,ab,ti OR para acetylaminophenol:tn,ab,ti OR para hydroxyacetanilide:tn,ab,ti OR para suppo:tn,ab,ti OR paracet:tn,ab,ti O

36、R paracetaminophenol:tn,ab,ti OR paracetamol:tn,ab,ti OR paracetamol ester:tn,ab,ti OR paracetamole:tn,ab,ti OR parageniol:tn,ab,ti OR paragin:tn,ab,ti OR paralen:tn,ab,ti OR paralief:tn,ab,ti OR paramax:tn,ab,ti OR paramidol:tn,ab,ti OR parapaed:tn,ab,ti OR parapaed junior:tn,ab,ti OR parapaed six

37、plus:tn,ab,ti OR paratabs:tn,ab,ti OR parvid:tn,ab,ti OR pasolind:tn,ab,ti OR pasolind n:tn,ab,ti OR paximol:tn,ab,ti OR pedipan:tn,ab,ti OR penral-night:tn,ab,ti OR perfalgan:tn,ab,ti OR phenaphen:tn,ab,ti OR pinex:tn,ab,ti OR polarfen:tn,ab,ti OR predimol:tn,ab,ti OR puernol:tn,ab,ti OR pyrigesic:

38、tn,ab,ti OR raperon:tn,ab,ti OR rapidol:tn,ab,ti OR relaphen:tn,ab,ti OR reliv:tn,ab,ti OR remedol:tn,ab,ti OR revanin:tn,ab,ti OR rhinapen elixir:tn,ab,ti OR rhodapap:tn,ab,ti OR roxamol gelcaps:tn,ab,ti OR salzone:tn,ab,ti OR sedes a:tn,ab,ti OR serimol:tn,ab,ti OR setamol:tn,ab,ti OR sinaspril:tn

39、,ab,ti OR sinedol:tn,ab,ti OR sinpro:tn,ab,ti OR tabalgin:tn,ab,ti OR tachipirin:tn,ab,ti OR tachipirina:tn,ab,ti OR taganopain:tn,ab,ti OR tapar:tn,ab,ti OR tempra:tn,ab,ti OR tempte:tn,ab,ti OR temzzard:tn,ab,ti OR termofren:tn,ab,ti OR tralgon:tn,ab,ti OR tralgon elixir:tn,ab,ti OR tramil:tn,ab,t

40、i OR treuphadol:tn,ab,ti OR turpan:tn,ab,ti OR tylenol:tn,ab,ti OR tylenol (caplet):tn,ab,ti OR tylenol (geltab):tn,ab,ti OR tylenol extra fuerte:tn,ab,ti OR tylenol forte:tn,ab,ti OR tylenol nr 1:tn,ab,ti OR tylex:tn,ab,ti OR valadol:tn,ab,ti OR winadol:tn,ab,ti OR winasorb:tn,ab,ti OR xebramol:tn,

41、ab,ti OR zolben:tn,ab,ti OR zydinol:tn,ab,ti AND (adverse drug reaction/exp OR adverse drug reaction:lnk OR adverse:de,ab,ti OR (side OR undesirable OR unwanted) NEXT/2 (effect* OR reaction* OR event* OR outcome*):de,ab,ti OR side effect/lnk OR side effect/exp OR complication/lnk OR complication/exp

42、 OR complication*:de,ab,ti OR worsening:de,ab,ti OR case report*:de,ab,ti OR pharmacovigilance:de,ab,ti OR postmarketing surveillance/exp OR drug interaction:lnk OR drug interaction/exp OR toxicity/exp OR drug toxicity:lnk OR toxic*:de,ab,ti OR intox*:de,ab,ti OR safety:de,ab,ti OR poison*:de,ab,ti

43、OR pharmacotox*:de,ab,ti OR neurotox*:de,ab,ti OR cardiotox*:de,ab,ti OR nephrotox*:de,ab,ti OR hepatotox*:de,ab,ti OR immunotox*:de,ab,ti OR immunocytotox*:de,ab,ti OR cytotox*:de,ab,ti OR carcinogen*:de,ab,ti OR cancerogen*:de,ab,ti OR mutagen*:de,ab,ti OR terato*:de,ab,ti OR fatal outcome/exp OR

44、death/exp OR death*:de,ab,ti OR suicide/exp OR suicid*:de,ab,ti OR mortal*:de,ab,ti OR fatal*:de,ab,ti OR risk/exp OR nocebo:de,ab,ti OR lethal concentration/exp OR iatrogenic disease/exp OR fertility/exp OR substance-related disorders/exp OR chemically induced:de,ab,ti OR morbidity:de,ab,ti OR cong

45、enital disorder:de,ab,ti OR infertility/exp OR injury/exp OR pregnancy/exp OR pregnant*:de,ab,ti OR pregnanc*:de,ab,ti OR pregnancy complication/exp OR pregnancy disorder/exp OR abortion/exp OR abortion:de,ab,ti OR lactation/exp OR breast feeding:de,ab,ti OR breastfeeding:de,ab,ti OR breast milk:de,

46、ab,ti OR reproduction/de OR fetus/de OR embryo/de OR prenatal:de,ab,ti OR perinatal:de,ab,ti OR newborn:de,ab,ti OR parameters concerning the fetus, newborn and pregnancy/exp OR aged/exp or elderly:de,ti,ab or geriatric*:ti,ab OR (environmental OR occupational) NEXT/1 exposure*):de,ab,ti OR compassi

47、onate use:de,ab,ti OR (named NEXT/1 (use OR patient*):ab,ti OR inappropriate prescri*:de,ab,ti OR drug metabolism/exp OR organ dysfunction:de,ab,ti OR organ failure:de,ab,ti OR hypersensitivit*:de,ab,ti OR allerg*:de,ab,ti OR counterfeit:de,ab,ti OR falsified drug:de,ab,ti OR (unavailab* NEAR/2 drug):de,ab,ti OR drug resistance/exp OR drug resistance:de,ab,ti OR withdrawal syndrome/de OR (drug* NEAR/3 (withdrawal OR toleran* OR interact* OR exposure* OR induc* OR resist* OR ineff* OR nonrespon* OR unrespon*):de,ab,ti OR drug tolerance/exp OR (drug* OR treatment) NEXT/1 (failu