Etoricoxib-hydrochloride-MK-0663-hydrochloride-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEEtoricoxibhydrochlorideCat.No.:HY-15321ACASNo.:202409-40-3Synonyms:MK-0663hydrochloride;L-791456hydrochloride分⼦式:C₁₈H₁₆Cl₂N₂O₂S分⼦量:395.3作⽤靶点:COX作⽤通路:Immunology/Inflammation储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Etoricoxibhydrochloride(MK-0663hydrochloride)⼀种合成的⾮甾体抗炎药，具有抑制环氧合酶-2的活性。Etoricoxibhydrochloride能够抑制花⽣四烯酸转化为前列腺素的过程，从⽽减少炎症和疼痛。Etoricoxibhydrochloride被⽤于抑制⾻关节炎，具有抗炎和⾻重建的效果。Etoricoxibhydrochloride的制剂通过乳液溶剂蒸发技术制备，表现出良好的细胞相容性和增强的碱性磷酸酶活性。REFERENCES[1].RiendeauD,etal.Etoricoxib(MK-0663):preclinicalprofileandcomparisonwithotheragentsthatselectivelyinhibitcyclooxygenase-2.JPharmacolExpTher.2001Feb;296(2):558-66.[2].KunakCS,etal.TheEffectofEtoricoxibonHepaticIschemia-ReperfusionInjuryinRats.OxidMedCellLongev.2015;2015:598162.[3].TanwarL,etal.Anti-proliferativeandapoptoticeffectsofetoricoxib,aselectiveCOX-2inhibitor,on1,2-dimethylhydrazinedihydrochloride-inducedcoloncarcinogenesis.AsianPacJCancerPrev.2010;11(5):1329-33.[4].Etoricoxib-loadedbio-adhesivehybridizedpolylacticacid-basednanoparticlesasanintra-articularinjectionforthetreatmentofosteoarthritisMcePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:021