Mitoxantrone-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEMitoxantrone(Standard)Cat.No.:HY-13502RCASNo.:65271-80-9分⼦式:C₂₂H₂₈N₄O₆分⼦量:444.48作⽤靶点:Topoisomerase;PKC;Orthopoxvirus;Apoptosis;EndogenousMetabolite作⽤通路:CellCycle/DNADamage;Epigenetics;TGF-beta/Smad;Anti-infection;Apoptosis;MetabolicEnzyme/Protease储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Mitoxantrone(Standard)Mitoxantrone的分析标准品。本产品⽤于研究及分析应⽤。Mitoxantrone⼀种有效的拓扑异构酶II(topoisomeraseII)抑制剂。Mitoxantrone也可抑制蛋⽩激酶C(PKC)，其IC50值为8.5μM。Mitoxantrone诱导B-慢性淋巴细胞⽩⾎病(B-CLL)细胞凋亡(apoptosis)。Mitoxantrone具有抗肿瘤活性[1][2][3][4]。Mitoxantrone还具有抗正痘病毒(orthopoxvirus)活性，对⽜痘和猴痘的EC50分别为0.25μM和0.8μM。IC50&TargetIC50:8.5μM(PKC)[1]REFERENCES[1].TakeuchiN,etal.InhibitoryeffectofmitoxantroneonactivityofproteinkinaseCandgrowthofHL60cells.JBiochem.1992Dec;112(6):762-7.[2].BellosilloB,etal.Mitoxantrone,atopoisomeraseIIinhibitor,inducesapoptosisofB-chroniclymphocyticleukaemiacells.BrJHaematol.1998Jan;100(1):142-6.[3].VibetS,etal.Differentialsubcellulardistributionofmitoxantroneinrelationtochemosensitizationintwohumanbreastcancercelllines.DrugMetabDispos.2007May;35(5):822-8.[4].FujimotoS,etal.Antitumoractivityofmitoxantroneagainstmurineexperimentaltumors:comparativeanalysisagainstvariousantitumorantibiotics.CancerChemotherPharmacol.1982;8(2):157-62.[5].SharonEAltmann,etal.Inhibitionofcowpoxvirusandmonkeypoxvirusinfectionbymitoxantrone.AntiviralRes.2012Feb;93(2):305-308.McePdfHeight1/1MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;