Efflux-inhibitor-1-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEEffluxinhibitor-1Cat.No.:HY-112505CASNo.:1776055-29-8分⼦式:C₂₈H₂₅N₅O₃分⼦量:479.53作⽤靶点:BCRP作⽤通路:MembraneTransporter/IonChannel储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性数据体外实验DMSO:50mg/mL(104.27mM;ultrasonicandwarmingandheatto60°C)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.0854mL10.4269mL20.8538mL5mM0.4171mL2.0854mL4.1708mL10mM0.2085mL1.0427mL2.0854mL体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(5.21mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(5.21mM);ClearsolutionBIOLOGICALACTIVITY1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE⽣物活性Effluxinhibitor-1(compound2)吡唑啉[1,5-a]嘧啶外排抑制剂。Effluxinhibitor-1在ABCG2/BCRP，ABCB1间选择性靶向ABCG2，IC50分别为0.45μM和2.17μM。IC50&TargetIC50:0.45μM(ABCG2/BCRP),2.17μM(ABCB1)[1]REFERENCES[1].Larson,etal.Selectiveeffluxinhibitorsandrelatedpharmaceuticalcompositionsandmethodsoftreatment:UnitedStates,US9056111[P].2015-06-16.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:0