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BobZhengWuhanUniversity1.BobZheng1.BonereplacementisthereplacementofoldbonetissuebynewbonetissueNevermetabolicallyatrestReplacingitselfthroughoutadultlife2.BonereplacementisthereplacRemodelingallowswornorinjuredbonetoberemovedandreplacedwithnewtissue3.RemodelingallowswornorinjuRemodelingallowsbonetoserveasthebody’sstorageareaforcalciumConstantsupplyofCa2+inthebloodstreamneededfor:TransmissionofnerveimpulsesMusclecontractionBloodcoagulationCelldivision4.RemodelingallowsbonetoservOsteoclastandosteoblast5.Osteoclastandosteoblast5.Sufficientquantitiesofcalcium(Ca)andphosphorus(P)6.SufficientquantitiesofcalciSufficientamountsofvitamins,particularlyvitaminD7.SufficientamountsofvitaminsProperamountsofthehormonesGrowthhormone(GH),Calcitonin(CT),Parathormone(PTH),Sexhormones8.ProperamountsofthehormonesSecretedbythepituitarygland,responsibleforgeneralgrowthofbonesToomuchGigantismToolittleDwarfism9.SecretedbythepituitaryglanCTisproducedbythethyroidgland,inhibitsosteoclasticactivityPTHissecretedbytheparathyroidglands,increasesthenumberandactivityofosteoclasts

AntagonisticCTPTH

10.CTisproducedbythethyroidControlofBoneDepositionControlofBoneResorption[Ca2+]controlledbynegativefeedbackloop11.ControlofBoneDepositionContPromotethegrowthofnewboneBringaboutthedegenerationofcartilagecells12.PromotethegrowthofnewboneAgingforskeletalsyetemhappenswhenOsteoblastactivitydeclines,whileosteoclastactivityremainslevelLossofcalciumfrombones13.13.Forfemale,thislossbeginsafterage40butformale,thislosstypicallydoesnotbeginuntilafter6014.Forfemale,thislossbeginsaMENOPAUSE!Remember,estrogen(sexhormoneforfemale)stimulatesosteoblastactivityandsynthesisofbonematrix

Mencontinuetoproduceandrogens(sexhormoneformale)intolatelifeandthusarenotasaffected.15.MENOPAUSE!MencontinuetoprAnothereffectforagingisthedecreaseintherateofproteinformationLessorganicmatrixmoreinorganicmatrixBonesbecomebrittleandeasytofracture16.AnothereffectforagingisthWhenthelossofbonemasscompromisesnormalfunctionapersonisdiagnosedwithosteoporosis.17.WhenthelossofbonemasscomPrematuremenopauseBodybuild–shortwomenhavelessbonemasstobeginwithWeight–thinneratgreaterriskSmoking–decreasesestrogenlevelsLackofdietarycalciumSedentarylifestyle–decreaserateofabsorptionDrugs–alcohol,cortisone,tetracyclineNulliparity(neverhadchildren)AncestryorFamilyhistory18.Prematuremenopause18.NosmokingTakeinmorecalciumDon’tsitallthedayBecarefulwhentakingdrugs19.Nosmoking19.20.20.BobZhengWuhanUniversity21.BobZheng1.BonereplacementisthereplacementofoldbonetissuebynewbonetissueNevermetabolicallyatrestReplacingitselfthroughoutadultlife22.BonereplacementisthereplacRemodelingallowswornorinjuredbonetoberemovedandreplacedwithnewtissue23.RemodelingallowswornorinjuRemodelingallowsbonetoserveasthebody’sstorageareaforcalciumConstantsupplyofCa2+inthebloodstreamneededfor:TransmissionofnerveimpulsesMusclecontractionBloodcoagulationCelldivision24.RemodelingallowsbonetoservOsteoclastandosteoblast25.Osteoclastandosteoblast5.Sufficientquantitiesofcalcium(Ca)andphosphorus(P)26.SufficientquantitiesofcalciSufficientamountsofvitamins,particularlyvitaminD27.SufficientamountsofvitaminsProperamountsofthehormonesGrowthhormone(GH),Calcitonin(CT),Parathormone(PTH),Sexhormones28.ProperamountsofthehormonesSecretedbythepituitarygland,responsibleforgeneralgrowthofbonesToomuchGigantismToolittleDwarfism29.SecretedbythepituitaryglanCTisproducedbythethyroidgland,inhibitsosteoclasticactivityPTHissecretedbytheparathyroidglands,increasesthenumberandactivityofosteoclasts

AntagonisticCTPTH

30.CTisproducedbythethyroidControlofBoneDepositionControlofBoneResorption[Ca2+]controlledbynegativefeedbackloop31.ControlofBoneDepositionContPromotethegrowthofnewboneBringaboutthedegenerationofcartilagecells32.PromotethegrowthofnewboneAgingforskeletalsyetemhappenswhenOsteoblastactivitydeclines,whileosteoclastactivityremainslevelLossofcalciumfrombones33.13.Forfemale,thislossbeginsafterage40butformale,thislosstypicallydoesnotbeginuntilafter6034.Forfemale,thislossbeginsaMENOPAUSE!Remember,estrogen(sexhormoneforfemale)stimulatesosteoblastactivityandsynthesisofbonematrix

Mencontinuetoproduceandrogens(sexhormoneformale)intolatelifeandthusarenotasaffected.35.MENOPAUSE!MencontinuetoprAnothereffectforagingisthedecreaseintherateofproteinformationLessorganicmatrixmoreinorganicmatrixBonesbecomebrittleandeasytofracture36.Anothereffectforagi

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