Letrozole-CGS-20267-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemELetrozoleCat. No.: HY-14248CAS No.: 112809-51-5Synonyms: CGS 20267分式: CHN分量: 285.3作靶点: Aromatase; Autophagy作通路: Others; Autophagy储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 50 mg/mL (17

2、5.25 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.5051 mL 17.5254 mL 35.0508 mL5 mM 0.7010 mL 3.5051 mL 7.0102 mL10 mM 0.3505 mL 1.7525 mL 3.5051 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；

3、澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (7.29 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (7.29 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oil1/2 Master of Sma

4、ll Molecules 您边的抑制剂师www.MedChemESolubility: 2.08 mg/mL (7.29 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Letrozole芳酶抑制剂，其 IC50 为1-13 nM。户使本产品发表的科研献 Mol Cancer Res. 2018 Mar;16(3):361-377. Exp Ther Med. 2018 Jun;15(6):5269-5274.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Hayne

5、s, B.P., et al., The pharmacology of letrozole. J Steroid Biochem Mol Biol, 2003. 87(1): p. 35-45.2. Bhatnagar, A.S., et al., Highly selective inhibition of estrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitor. JSteroid Biochem Mol Biol, 1990. 37(6): p. 1021-7.3. Dellapasqua,

6、S. and M. Colleoni, Letrozole. Expert Opin Drug Metab Toxicol, 2010. 6(2): p. 251-9.4. Lee, K., et al., An in vivo model of intratumoural aromatase using aromatase-transfected MCF7 human breast cancer cells. Int J Cancer,1995. 62(3): p. 297-302.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-8