NSC-185058 - ATG4B 抑制剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemENSC 185058Cat. No.: HY-125169CAS No.: 39122-38-8分式: CHNS分量: 215.27作靶点: Cathepsin; Autophagy作通路: Metabolic Enzyme/Protease; Autophagy储存式: 4C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (protect fromlight)溶解性数据

2、体外实验 DMSO : 125 mg/mL (580.67 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 4.6453 mL 23.2266 mL 46.4533 mL5 mM 0.9291 mL 4.6453 mL 9.2907 mL10 mM 0.4645 mL 2.3227 mL 4.6453 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先

3、配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (9.66 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (9.66 mM); Clear solution3.

4、请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (9.66 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 NSC 185058种 ATG4B 抑制剂。ATG4B 种主 的半胱氨酸蛋酶 (cysteine protease)。NSC185058抑制 ATG4B 从显著减弱噬 (autophagic) 活性 1。IC50 & Target ATG4B 1Autophagy 1体内研究 NSC185058

5、 is an ATG4B antagonist. ATG4B stimulates autophagy by promoting autophagosome formationthrough reversible modification of ATG8. Inclusion of the ATG4B inhibitor NSC185058 enhances the anti-tumor activity of radiation therapy (RT). NSC185058 decreases glioblastoma (GBM) cell tumorigenicity, andenhan

6、ces the anti-tumor activity of RT when applied to orthotopic GBM xenograft models 1.REFERENCES1. Huang T, et al. MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma.Cancer Cell. 2017 Dec 11;32(6):840-855.e8.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400