LDN-214117 _TGF-β Receptor 抑制剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemELDN-214117Cat. No.: HY-16712CAS No.: 1627503-67-6分式: CHNO分量: 419.52作靶点: TGF- Receptor作通路: TGF-beta/Smad储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (238.37 mM)* means soluble,

2、but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.3837 mL 11.9184 mL 23.8368 mL5 mM 0.4767 mL 2.3837 mL 4.7674 mL10 mM 0.2384 mL 1.1918 mL 2.3837 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清

3、的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.96 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (5.96 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oil1/2 Master of Small M

4、olecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (5.96 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 LDN-214117ALK2效选择性抑制剂，IC50值为22nM,也能抑制BMP6，IC50值为100nM,对ALK5抑制弱100倍。REFERENCES1. Mohedas AH, et al. Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity forfibrodysplasia ossificans progressiva causing mutants. J Med Chem. 2014 Oct 9;57(19):7900-15.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;