Isoliquiritigenin-GU17-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEIsoliquiritigeninCat. No.: HY-N0102CAS No.: 961-29-5Synonyms: GU17; ISL; Isoliquiritigen分式: CHO分量: 256.25作靶点: Aldose Reductase; Autophagy作通路: Metabolic Enzyme/Protease; Autophagy储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C

2、6 months-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (390.24 mM)Ethanol : 100 mg/mL (390.24 mM; Need ultrasonic)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.9024 mL 19.5122 mL 39.0244 mL5 mM 0.7805 mL 3.9024 mL 7.8049 mL10 mM 0.3902 mL 1.9512 mL 3.9024 mL请根据

3、产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (9.76 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (2

4、0% SBE-CD in saline)1/3 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (9.76 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (9.76 mM); Clear solution4. 请依序添加每种溶剂： 10% EtOH 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (9.76 mM); Clear solutio

5、n5. 请依序添加每种溶剂： 10% EtOH 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (9.76 mM); Clear solution6. 请依序添加每种溶剂： 10% EtOH 90% corn oilSolubility: 2.5 mg/mL (9.76 mM); Suspended solutionBIOLOGICAL ACTIVITY物活性 Isoliquiritigenin从光果草根中分到的黄酮类化合物，具有抗肿瘤的活性，能够抑制 aldose reductase 的活性，IC50 值为 320 nM。IC50 & Targ

6、et IC50: 320 nM (Aldose reductase)体外研究 Isoliquiritigenin may prevent diabetic complications through inhibiting rat lens aldose reductase with an IC50of 320 nM and sorbitol accumulation in human red blood cells with an IC50 of 2.0 M 1. Isoliquiritigenin (100M) markedly inhibits the hypoxia-induced pr

7、olonged TPS and TR90 of cardiomyocytes. Isoliquiritigeninsignificantly triggers AMPK Thr172 phosphorylation as compared with vehicle group. Isoliquiritigenintreatment also induces extracellular signal-regulated kinase (ERK) signaling pathway in the cardiomyocytes.Isoliquiritigenin treatment signific

8、antly decreases the intracellular ROS levels of isolated cardiomyocytesduring hypoxia/reoxygenation 3. Isoliquiritigenin not only downregulates IL-6 expression but alsosignificantly decreases levels of phosphorylated ERK and STAT3 and can inhibit phosphorylation levels ofERK and STAT3 induced by rec

9、ombinant human IL-6, which are critical signaling proteins in IL-6 signalingregulation networks 4.体内研究 Isoliquiritigenin shows concentration-dependent inhibition of the tonic contraction of mouse jejunum inducedby various types of stimulants such as CCh (1 mM), KCl (60 mM) and BaCl2 (0.3 mM) with IC

10、50 values of4.961.97 mM, 4.031.34 mM and 3.700.58 mM, respectively 2. Isoliquiritigenin exhibits significant anti-tumor activity in MM xenograft models and synergistically enhances the anti-myeloma activity of adriamycin4.户使本产品发表的科研献 Am J Transl Res. 2018 Dec 15;10(12):4141-4151. Onco Targets Ther.

11、2018 Mar 22;11:1633-1642. Oncol Lett. 2018 Nov;16(5):6133-6139. Chemotherapy. 2018 Jun 22;63(3):155-161. Open Life Sci. 2017; 12: 300307See more customer validations on HYPERLINK / www.MedChemE2/3 Master of Small Molecules 您边的抑制剂师www.MedChemEREFERENCES1. Aida K, et al. Isoliquiritigenin: a new aldos

12、e reductase inhibitor from glycyrrhizae radix. Planta Med. 1990 Jun;56(3):254-8.2. Sato Y, et al. Isoliquiritigenin, one of the antispasmodic principles of Glycyrrhiza ularensis roots, acts in the lower part of intestine. BiolPharm Bull. 2007 Jan;30(1):145-9.3. Zhang X. Natural antioxidant-isoliquiritigenin ameliorates contractile dysfunction of hypoxic cardiomyocytes via AMPK signaling pathway.Mediators Inflamm. 2013;2013:390890.4. Chen X, et al. Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling. J Mol Med (Berl). 2012Nov;90(11):1311-9.McePdfHe