ATP-Synthase-Inhibitors-Modulators-MCE

1、 HYPERLINK https:/www.MedChemE/Targets/ATP Synthase.html ATP HYPERLINK https:/www.MedChemE/Targets/ATP Synthase.html HYPERLINK https:/www.MedChemE/Targets/ATP Synthase.html SynthaseATPases are a class of enzymes that catalyze the decompositionof ATP into ADP and a free phosphate ion. This dephosphor

2、ylationreaction releases energy, which the enzyme (in most cases) harnesses to drive other chemical reactions that would not otherwiseoccur. Some such enzymes are integral membrane proteins and move solutes across the membrane, typically against theirconcentration gradient. These are called transmem

3、brane ATPases. Transmembrane ATPases import many of the metabolitesnecessary for cell metabolism and export toxins, wastes, and solutes that can hinder cellular processes. Such as thesodium-potassium exchanger (or Na+/K+ ATPase) and the hydrogen potassium ATPase (H+/K+ ATPase or gastric proton pump)

4、 thatacidifies the contents of the stomach.www.MedChemE 1 HYPERLINK https:/www.MedChemE/Targets/ATP Synthase.html ATP HYPERLINK https:/www.MedChemE/Targets/ATP Synthase.html HYPERLINK https:/www.MedChemE/Targets/ATP Synthase.html Synthase HYPERLINK https:/www.MedChemE/Targets/ATP Synthase.html HYPER

5、LINK https:/www.MedChemE/Targets/ATP Synthase.html Inhibitors HYPERLINK https:/www.MedChemE/apoptolidin.html Apoptolidin HYPERLINK https:/www.MedChemE/apoptolidin.html HYPERLINK https:/www.MedChemE/atp-synthase-inhibitor-1.html ATP HYPERLINK https:/www.MedChemE/atp-synthase-inhibitor-1.html HYPERLIN

6、K https:/www.MedChemE/atp-synthase-inhibitor-1.html synthase HYPERLINK https:/www.MedChemE/atp-synthase-inhibitor-1.html HYPERLINK https:/www.MedChemE/atp-synthase-inhibitor-1.html inhibitor HYPERLINK https:/www.MedChemE/atp-synthase-inhibitor-1.html HYPERLINK https:/www.MedChemE/atp-synthase-inhibi

7、tor-1.html 1Cat. No.: HY-126679 Cat. No.: HY-112715Apoptolidin is a polyketide isolated fromNocardiopsis bacteria. Apoptolidin is aselective mitochondrial F F ATPase inhibitor.1 OATP synthase inhibitor 1 is a potent inhibitor ofc subunit of the F /F -ATP synthase complex,1 Oinhibits mitochondrial pe

8、rmeability transitionpore (mPTP) opening, does not affect ATP levels.Purity: 95.0%Clinical Data: No Development ReportedSize: 100 gPurity: 99.84%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/bongkrekic-acid.html Bongkrekic HYPERLINK https

9、:/www.MedChemE/bongkrekic-acid.html HYPERLINK https:/www.MedChemE/bongkrekic-acid.html acid HYPERLINK https:/www.MedChemE/bongkrekic-acid.html HYPERLINK https:/www.MedChemE/BTB06584.html BTB06584Cat. No.: HY-136406 Cat. No.: HY-15877Bongkrekic acid is a mitochondrial toxinsecreted by the bacteria Ps

10、eudomonascocovenenans. Bongkrekic acid specific ligand formitochondrial adenine nucleotide translocase (ANT)rather than the electron transport chain.BTB06584 is a selective and IF1-dependentmitochondrial F F -ATPase inhibitor without1 ocompromising ATP synthesis. BTB06584 can delaysischaemic cell de

11、ath.Purity: 95.0%Clinical Data: No Development ReportedSize: 500 gPurity: 99.83%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/d-hydroxyglutaric-acid.html D-Hydroxyglutaric HYPERLINK https:/www.MedChemE/d-hydroxyglutaric-acid.html HYP

12、ERLINK https:/www.MedChemE/d-hydroxyglutaric-acid.html acid HYPERLINK https:/www.MedChemE/d-hydroxyglutaric-acid.html (R)-2-Hydroxyglutarate;(R)-2-Hydroxyglutaric acid; ) Cat. No.: HY-113038 HYPERLINK https:/www.MedChemE/D-alpha-Hydroxyglutaric-acid-disodium-salt.html D-Hydroxyglutaric HYPERLINK htt

13、ps:/www.MedChemE/D-alpha-Hydroxyglutaric-acid-disodium-salt.html HYPERLINK https:/www.MedChemE/D-alpha-Hydroxyglutaric-acid-disodium-salt.html acid HYPERLINK https:/www.MedChemE/D-alpha-Hydroxyglutaric-acid-disodium-salt.html HYPERLINK https:/www.MedChemE/D-alpha-Hydroxyglutaric-acid-disodium-salt.h

14、tml disodium(Disodium (R)-2-hydroxyglutarate) Cat. No.: HY-100542D-Hydroxyglutaric acid (R)-2-Hydroxyglutarate)is the principal metabolite accumulating inneurometabolic disease D-2-hydroxyglutaricaciduria.D-Hydroxyglutaric acid disodium (Disodium(R)-2-hydroxyglutarate) is the principalmetabolite acc

15、umulating in neurometabolic diseaseD-2-hydroxyglutaric aciduria.Purity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mgPurity: 98.0%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 10 mg, 25 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/Gboxin.html Gboxin HYPERLINK https:/

16、www.MedChemE/Gboxin.html HYPERLINK https:/www.MedChemE/kusc-5037.html KUSC-5037Cat. No.: HY-111651 Cat. No.: HY-144750Gboxin is an oxidative phosphorylation (OXPHOS)inhibitor that targets glioblastoma. Gboxininhibits the activity of F F ATP synthase.0 1Antitumour activity.KUSC-5037 is a potent HIF-1

17、 inhibitor (IC =1.250M). KUSC-5037 inhibits mitochondrial respiratorycomplex V and F F -ATP synthase.o 1Purity: 99.49%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/oligo

18、mycin.html Oligomycin HYPERLINK https:/www.MedChemE/oligomycin.html HYPERLINK https:/www.MedChemE/Oligomycin_A.html Oligomycin HYPERLINK https:/www.MedChemE/Oligomycin_A.html HYPERLINK https:/www.MedChemE/Oligomycin_A.html ACat. No.: HY-N6782(MCH 32) Cat. No.: HY-16589Oligomycin, an antifungal antib

19、iotic, is aninhibitor of H+-ATP-synthase. Oligomycin blocksoxidative phosphorylation and the electrontransport chain. Oligomycin inhibits HIF-1alphaexpression in hypoxic tumor cells.Oligomycin A (MCH 32), created by Streptomyces,acts as a mitochondrial F F -ATPase inhibitor,0 1with a K of 1 M; Oligo

20、mycin A shows anti-fungaliactivity.Purity: 98.53%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mgPurity: 99.94%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg2 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/oligomycin-b.html Oligomycin HYPERLINK https:/www.MedChemE/ol