淋巴造血系统结构.ppt

DISEASESOFLYMPHOIDANDHEMATOPOIETICTISSUES/SYSTEM淋巴造血组织系统疾病淋巴网状组织：结构和功能,天津医科大学病理学教研室,ORGANS器官Reactivehyperplasia(benign)Thymus胸腺反应性增生(良性)Spleen脾Lymphnodes淋巴结Neoplastichyperplasia(malignant：Lymphoma)Tonsils扁桃体肿瘤性增生(恶性：淋巴瘤)DISSEMINATED散在性Hodgkinlymphoma霍奇金淋巴瘤(HL)alloverthebodyNon-Hodgkinlymphoma非霍奇金淋巴瘤(NHL)Skin皮肤B-cellneoplsmsB细胞淋巴瘤GI消化道T/NK-cellneoplsmsT/NK细胞淋巴瘤RS呼吸系统Lymphocyticleukemia淋巴细胞性白血病US泌尿系统HistiocyticusuallyCD4+/helperandCD57+)Histiocytes组织细胞Tingiblebodymacrophages可染小体巨噬细胞(CD68+)Marginalzone边缘区Marginalzonecells边缘区细胞/MonocytoidBcells单核细胞样B细胞(IgM)Interfollicularzone滤泡间区TcellzoneT细胞区TlymphocytesT淋巴细胞(CD4CD8)Interdigitatingdendriticcells(2)PARACORTEX副皮质(Deepcortex深皮质)交指样树状突细胞(IDC)*(S-100+)TransformedBcells转化性B淋巴细胞(3)MEDULLAPCV毛细血管后小静脉Medullarycords髓索BcellzoneB细胞区:Plasmacytoidlymphocytes淋巴浆细胞样淋巴细胞(CD20,IgM+)Plasmacells浆细胞(CD38+,CD138+,IgG+,+/+)*FCD,ICDandLC(Langerhanscells):Accessarycellsofimmunity免疫辅佐细胞PCV=Postcappillaryvenules(Highendothelialvenules,HEV高内皮小静脉),Lymphoidparenchyma淋巴组织实质,Cortex皮质：PrimaryFollicles初级滤泡,Theevolutionoffollicles淋巴滤泡的演化,Directionofantigeninflux,Mantlezonethickeratthetop(corona),Lightzoneofgerminalcenter,Darkzoneofgerminalcenter(morelargecells),Lightzone,Darkzone,Starysky,Starysky,Centrocytes,Centroblasts,Tingiblebodycells,FDC,FDC,CD21(FDC),中心母细胞中心细胞,浆母细胞,CD20(Bcdlls),CD45RO(Tcells),Organizationofsecondarylymphoidfollicle,Marginalzonecells(IgM),Mantlezonecells(IgM+D),Folliclecentercells(IgM,IgG,IgAorIgE,notIgD),Mentlezone/Mentlecells淋巴滤泡：套层/套细胞,Marginalzone/Marginalcells(MonocytoidBcells)淋巴滤泡：边缘区/边缘区细胞(单核细胞样B细胞),*,*,*,*,Ma,C,M,Ca,S,Ma,C,M,Ca,S,MantlezoneMantlecells,Mantlezone,Marginalzone,Paracortex,Paracortex,IDC,Paracortex,CD3,CD20,Sinushistiocytes,Medullarycords/Plasmacells,AfferentlympaticsSinusesEfferentlympatic输入淋巴管淋巴窦输出淋巴管SINUSES:Supcapsular/PeripheralS包膜下窦/边缘窦Paratrabecular/IntermediateS小梁旁窦/中间窦SinushistiocytesMedullaryS髓窦HilarS门窦ArteryCapillaryiesPostcapillaryvenules(PCV*)Vein动脉毛细血管毛细血管后小静脉静脉*PCV=Postcappillaryvenules(Highendothelialvenules,HEV高内皮小静脉/Epithelioidvenules,EV上皮样小静脉)intheparacortex:permittinglymphocytestotrafficthroughthem/recir