Sarizotan-dihydrochloride-EMD-128130-dihydrochloride-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemESarizotandihydrochlorideCat.No.:HY-100820BCASNo.:177976-12-4Synonyms:EMD128130dihydrochloride分子式:C₂₂H₂₃Cl₂FN₂O分子量:421.34作用靶点:5-HTReceptor;DopamineReceptor作用通路:GPCR/GProtein;NeuronalSignaling储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Sarizotandihydrochloride(EMD128130)是具有口服活性的5-HT1A受体和多巴胺受体的激动剂，其IC50值分别为6.5nM(rat5-HT1A)、0.1nM(human5-HT1A)、15.1nM(ratD2)、17nM(humanD2)、6.8nM(humanD3)和2.4nM(humanD4.2)。IC50&Target5-HT1AReceptorHumanD3Receptor5-HT2AReceptor5-HT2BReceptor0.1nM(IC50)6.8nM(IC50)587nM(IC50)108nM(IC50)5-HT5AReceptorHuman5-HT6Human5-HT7313nM(IC50)ReceptorReceptor3300nM(IC50)10nM(IC50)客户使用本产品发表的科研文献• CellDeathDis.2024Jun12;15(6):411.Seemorecustomervalidationsonwww.MedChemEREFERENCESGDBartoszyk,etal.Sarizotan,aSerotonin5-HT1AReceptorAgonistandDopamineReceptorLigand.JNeuralTransm(Vienna).2004Feb;111(2):113-26.1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemECMarin,etal.LocalAdministrationofSarizotanIntotheSubthalamicNucleusAttenuatesLevodopa-InducedDyskinesiasin6-OHDA-lesionedRats.Psychopharmacology(Berl).2009Jun;204(2):241-50.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax:02