minus-5-HT2C-agonist-3-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemE(-)-5-HT2Cagonist-3Cat.No.:HY-156532CCASNo.:2104810-16-2分子式:C₁₉H₂₃ClFNO₂分子量:351.84作用靶点:5-HTReceptor作用通路:GPCR/GProtein;NeuronalSignaling储存方式: 4°C,sealedstorage,awayfrommoistureInsolvent:-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)溶解性数据体外实验DMSO:100mg/mL(284.22mM;Needultrasonic)SolventMass1mg5mg10mgConcentration制备储备液1mM2.8422mL14.2110mL28.4220mL5mM0.5684mL2.8422mL5.6844mL10mM0.2842mL1.4211mL2.8422mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存方式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。BIOLOGICALACTIVITY生物活性(-)-5-HT2Cagonist-3(compound(–)-19)是一种具有Gq信号偏好的5-HT2C选择性激动剂，对5-HT2受体的EC50值分别为5-HT2C：103nM;5-HT2B:570nM;5-HT2A:72nM。(-)-5-HT2Cagonist-3可用于抗精神病的研究。IC50&Target5-HT2AReceptor5-HT2CReceptor5-HT2BReceptor72nM(IC50)103nM(IC50)570nM(IC50)1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemEREFERENCESGuipingZhang,etal."DiscoveryofN-substituted(2-phenylcyclopropyl)methylaminesasfunctionallyselectiveserotonin2Creceptoragonistsforpotentialuseasantipsychoticmedications."Journalofmedicinalchemistry60.14(2017):6273-6288.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax:021