Tegafur-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemETegafur(Standard)Cat.No.:HY-17400RCASNo.:17902-23-7分⼦式:C₈H₉FN₂O₃分⼦量:200.17作⽤靶点:NucleosideAntimetabolite/Analog作⽤通路:CellCycle/DNADamage储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Tegafur(Standard)Tegafur的分析标准品。本产品⽤于研究及分析应⽤。Tegafur(FT207;NSC148958)是抗癌剂5-FU的前体。IC50&TargetNucleosideantimetabolite/analogREFERENCES[1].SotaroSadahiro,ToshiyukiSuzuki,AkiraTanaka,etal.Associationofright-sidedtumorswithhighthymidinephosphorylasegeneexpressionlevelsandtheresponsetooraluracilandtegafur/leucovorinchemotherapyamongpatientswithcolorectalcancer.CancerChemotherapyandPharmacology.2012,70(2):285-291.[2].JoséL.Ariasa,etal.Engineeringofanantitumor(core/shell)magneticnanoformulationbasedonthechemotherapyagentftorafur.ColloidsandSurfacesA:PhysicochemicalandEngineeringAspects.2011,384(1-3):157-163.[3].GabrielN.Hortobagyi,WilliamHeim,LauraHutchins,etal.Aphase2studyofafixedcombinationofuracilandftorafur(UFT)andleucovoringivenorallyina3-times-dailyregimentotreatpatientswithrecurrentmetastaticbreastcancer.Cancer.2010,116(6):1440-1445.[4].K.Fujita,H.Nakayama,W.Ichikawa,etal.Pharmacokineticsof5-FluorouracilinElderlyJapanesePatientswithCancerTreatedwithS-1(aCombinationofTegafurandDihydropyrimidineDehydrogenaseInhibitor5-Chloro-2,4-dihydroxypyridine).DrugMetabDispos.2009Jul;37(7):1375-7.doi:10.1124/dmd.109.027052.Epub2009Apr23.[5].Tegafur-uracilMcePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-