T3SS-IN-5-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemET3SS-IN-5Cat.No.:HY-158320分子式: C₁₆H₁₄N₂OS₂分子量: 314.43作用靶点: Bacterial作用通路: Anti-infection储存方式: PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性T3SS-IN-5(CompoundF9)是毒力因子中的第三型分泌系统（T3SS）的特异性抑制剂。T3SS-IN-5通过抑制T3SS相关基因的表达，来减少细菌的致病性而不影响细菌的生存能力[1]。体外研究T3SS-IN-5(200μM;48h)hasnostatisticallysignificanteffectontheviabilityofXcc[1].T3SS-IN-5(200μM;5d)causesasignificantreductioninXcc-jx-6-inducedhypersensitiveresponse(HR)inNicotianabenthamiana[1].T3SS-IN-5(200μM;4-7d)reducestheulcerativesymptomsoforachorangeandismoreeffectivethanbismerthiazolatthesameconcentration[1].T3SS-IN-5(200μM;16h)significantlyreducestherelativeincidenceofXcc[1].T3SS-IN-5(200μM;48h-5d)doesnotaffectothervirulencefactorsofXcc,includingextracellularenzymesactivity,EPSactivity,motility,andbiofilmformation[1].T3SS-IN-5(100-200μM;4d)combineswithBurkholderiaanthinahN-8canfurtherimprovetheinhibitionofXcc[1].RT-PCR[1]CellLine:hrpclusterConcentration:200μMIncubationTime:16hResult:SignificantlyreducedtheexpressionlevelsofkeyT3SSgenes(hrpG,hrpX,hrpE,hrcC,hrcT,andhpa1)intheXcc.Significantlyreducedtheexpressionofthecriticaldiseasesusceptibilitygene,Citrus1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemEsinensislateralorganboundary1(CsLOB1).REFERENCESZhangYQ,etal.DesignandSynthesisofMandelicAcidDerivativesforSuppressionofVirulenceviaT3SSagainstCitrusCanker.JAgricFoodChem.2024May1;72(17):9611-9620.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;02