Azilsartan-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEAzilsartan(Standard)Cat.No.:HY-14914RCASNo.:147403-03-0分⼦式:C₂₅H₂₀N₄O₅分⼦量:456.45作⽤靶点:AngiotensinReceptor;ReactiveOxygenSpecies;Apoptosis作⽤通路:GPCR/GProtein;Immunology/Inflammation;MetabolicEnzyme/Protease;NF-κB;Apoptosis储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Azilsartan(Standard)Azilsartan的分析标准品。本产品⽤于研究及分析应⽤。Azilsartan(TAK-536)⼀种⼝服有效的、选择性和特异性的⾎管紧张素Ⅱ1型受体(AT1)拮抗剂。Azilsartan诱导HepG2细胞ROS形成和细胞凋亡(apoptosis)。Azilsartan具有神经保护和抗癌活性。Azilsartan可以⽤于⾼⾎压和中风研究。REFERENCES[1].KajiyaT,etal.Molecularandcellulareffectsofazilsartan:anewgenerationangiotensinIIreceptorblocker.JHypertens.2011Dec;29(12):2476-83.[2].ZhaoM,etal.AzilsartantreatmentimprovesinsulinsensitivityinobesespontaneouslyhypertensiveKoletskyrats.DiabetesObesMetab.2011Dec;13(12):1123-9.[3].OjimaM,etal.Invitroantagonisticpropertiesofanewangiotensintype1receptorblocker,azilsartan,inreceptorbindingandfunctionstudies.JPharmacolExpTher.2011Mar;336(3):801-8.[4].GuptaV,etal.Neuroprotectivepotentialofazilsartanagainstcerebralischemicinjury:Possibleinvolvementofmitochondrialmechanisms.NeurochemInt.2020Jan;132:104604.[5].AhmadianE,etal.Novelangiotensinreceptorblocker,azilsartaninducesoxidativestressandNFkB-mediatedapoptosisinhepatocellularcarcinomacelllineHepG2.BiomedPharmacother.2018Mar;99:939-946.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58955