【北京大学-病理学试题知识点】-4肿瘤

For09基础byCS病理第四章肿瘤自测网题C.Carcinomaoftheesophagus共74题D.FollicularlymphomaWhichoneofthefollowingstatementsismostappropriateforthelesionshownhere?A.Thistumorisalways注：3、4、5、6题有图见附Workersinthedyeindustryaremostpronetowhichofthefollowingtumors?A.AarcinomaofthelungFB.SqUamoUScellcarcinomaoftheskin/C.Basalcellcarcinomaoftheskin/D.CarcinomaofthestomachE.CarcinomaoftheurinarybladderWhichofthefollowingtumorshasbeenassociatedmoststronglywithapossibleviraletiology?A.CarcinomaofthelungBB.Burkitt'slymphomaE.FibrosarcomaA72yearoldfemalehasbeenfeelingfatiguedforweeks.Shehashada10kgweightlossinthepastcoupleofmonths.Shehassomenausea,butnovomiting,hemoptysis,orhematemesis.Shedoesnothaveacough.Sheisafebrile.Themostlikelyexplanationforthesefindings,fromthegrossappearanceoftheliverseenhere,isthepresenceof:¥「HepaticadenomasMetastaticadenocarcinomaHepatocellularcarcinomaThistumorshouldexpressAFPoncofetalproteinMicronodularcirrhosiswell-differentiatedThegrowthpatternforthetumorislocalinvasion*CMetastasismaybeexistwhenthetumorisidentifiedTheetiologyofthetumorisrelatedtospecificvirusNoneofaboveA40-year-oldfemalehasnotedsomeintermenstrualbloodingandfeltpelvicdiscomfort.Apelvicexaminationisperformedandthecervicallesionseenhereisfoundandahysterectomyperformed.Whichoneofthefollowingstatementsismostappropriatebasedontheappearanceofthislesion?ThislesionistheresultofsmokingFor09基础byCSThisisabenignlesionthatwillnotrecur/1C.ThisisamalignantlesionthatwillbelethalThiskindoftumorisnotrelatedtoHPVSyphilisisthemaincauseofthelesionA68-year-oldmaleisfoundtohaveoccultbloodinthestoolonPhySidalexamination.Acolonoscopyisperformed,andthelesionseenherewasfoundandresected.Whichofthefollowingstatementsismostappropriateforthispatient?HischildrenhaveahighriskforasimilarlesionThisisabenignlesionthatwillnotrecurAsexuallytransmitteddiseaseledtothislesionMetastasesfromthislesionmaybepresentWhichofthefollowingisthemostcommongrowthpatternfortransitionalcellcarcinoma?Ulcerative产「B.OdularLeatherlikeCysticPapillaryBasalcellcarcinomaismostcommoninwhichlocationintheelderly?Hands*广B.FaceLiverTrunkThemostcommoncauseofdeathfromcancerinChinaisStomachcancerιl'^''B.LivercancerLungcancerBreastcancerColoncancerWhichoneofthefollowingitemsismosthelpfulindistinguishingpoorlydifferentiatedcarcinomafromsarcoma?ThegrowthpatternThemannerofspreadC.ThislesionistheresultofsmokingC.FeetC.TheageofpatientFor09基础byCSD.ThelocationofthetumorEE.RetiCuIumfiberstainSeedingmetastasisismostcommoninwhichofthefollowingmalignancies?MelanomaGastricsignet-ringcarcinomaBreastcarcinoma*「D.Osteosarcoma,广SquamouscarcinomaofpenisWhichonethefollowingofstatementsconcerningthetotalcellcycletimeintumorsismostappropriatewhenitiscomparedwithnormalcells?3timesfasterthanthatofnormalcells2timesfasterthanthatofnormalcellsEqualorevenlongerthanthatofnormalcells5timesfasterthanthatofnormalcellsMuchslowerthanthatofnormalcells13.AnalysisofcancerswhichhavemetastasizedrevealsamutationwhichresultsindecreasedcellsurfaceexpressionofE-cadherin.Whichofthefollowinggenesismostlikelymutatedtoproducethesefindings?Beta-cateninCyclinDBRCA-2NF-1RbPatientswithlong-standingEpstein-Barrvirusinfectionhaveanincreasedriskfordevelopmentofmalignantneoplasmsinadulthood.Whichofthefollowingneoplasmsismostlikelytobefoundinthesepatients?-⅛KaposisarcomaLipomaCervicalcarcinoma√广D.NasopharyngealcarcinomaEndometrialcarcinomaApreviouslyhealthy67-year-oldmanhasbeenfeelingtiredfor5months.Acompletephysicalexaminationisperformedandstoolguaiacispositive.Acolonoscopyisperformed,andalarge,sessile4.0cmmasswithsurfaceulcerationisfoundinthececum.Abiopsyofthismassmicroscopicallyshowsirregularglandswithcrowded,tallcolumnarcellshavingmarkednuclearhyperchromatism.Whichofthefollowingstatementsabouthisconditionismostaccurate?Hehashereditarynon-polyposiscoloncancerFor09基础byCSAp53mutationispresentintheneoplasticcellsThereislackofapoptosisfromafaultyBcl-2geneHisrelativeshavehereditaryadenomatouspolyposisHehasinheritedafaultyRbgenefromoneparentCellsofurothelialcarcinomademonstrateasinglemutationcausingcellularinabilitytohydrolyzeGTP,thusresultingincellulartransformation.Whichofthefollowingoncogenesismostlikelyimplicatedinthiscase?c-ablc-sisE.c-mycItisknownthatsomepre-existingconditionsarefoundtoprecededevelopmentofmalignantneoplasms.Whichofthefollowingconditionsismostlikelytobestatisticallyunrelatedtosubsequentmalignancy?Cervicalsquamousdysplasia-广ChronicalcoholismwithhepaticcirrhosisEndometrialatypicalhyperplasiaUterineleiomyomaChroniculcerativecolitisAnunequivocalfeaturesofmalignancyis-广CellularpleomorphismMetastasesNecrosisA62-year-oldmanwithan80packyearhistoryofsmokingexperiencesanepisodeofhemoptysis.Onphysicalexaminationhisfaceshowspuffiness,thereissomepedaledemaandbruisesontheskin,andhisbloodpressureis165/100mmHg.Achestradiographrevealsa5cmrightupperlobelungmass.Afineneedleaspirationofthismassshowssmallcellcarcinoma.Abonescanshowsnometastases.Immunohistochemicalstainingofthetumorcellsislikelytobepositiveforwhichofthefollowinghormones?ParathormonerelatedpeptideErythropoietinC.k-rasD.c-neuB.LymphocyticinfiltrationattheedgeofthetumorC.ACTHD.InsulinC.NumerousmitoticfiguresFor09基础byCSE.GastrinA25-year-oldwomaninexcellenthealthfounda2Cmfirm,roundedmassbeneaththeSkinofherupperback.TheoverlyingSkinappearsnormal.Themassispalpableandsoft.Shehasnosymptomovermanyyears.Whichofthefollowingneoplasmsisshemostlikelytohave?mitoses.Thecharacterizationofthispopulationoflymphocytesasaneoplasmisbestaccomplishedbywhichofthefollowingmethods?ImmunohistochemicalstainingidentifyingleukocytecommonantigenGenerearrangementstudiesthatThereismulticentricoriginofabenignneoplasmTheprimaryneoplasmisinthestomachAcarcinogenwastheunderlyingcausefortheneoplasmA.Metastaticcarcinoma■>-B.MelanomaLeiomyomaLipomaFibrosarcomaA14-year-oldboyhashadlumpsintherightneckforthepast5months.OnphysicaldemonstrateclonalityAdifferentialwhitebloodcountshowingalymphocytosisFlowcytometryindicatingahighS-phaseDemonstratingnecrosiswithinthemassbylightmicroscopyA58-year-oldmandiesafterayear-longillness.AtautopsythelivercontainsmultipleTheneoplasmisatanadvancedstageTheneoplasmishighgrade