生物药剂学与药代动力学课件 第九章 同一药物不同剂型给药后的血药浓度时间数据及统计矩参数计算过程

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,同一药物不同剂型给药后的血药浓度时间数据及统计矩参数计算过程,,,,,,,,,,,,,,,,,

,参数,X0,剂型,t(h),,,,,,,,,,,,,,

,,mg,,0.00,1.00,2.00,3.00,5.00,7.00,9.00,13.00,15.00,18.00,22.00,25.00,30.00,38.00,48.00

,C,300,静脉注射液,30.00,27.00,24.50,22.00,17.55,14.50,11.50,7.60,6.20,4.50,2.95,2.10,1.25,0.54,0.19

,mg/L,500,口服溶液,0.00,30.00,35.00,35.00,28.75,23.75,18.75,12.50,10.38,7.50,5.00,3.50,2.10,0.92,0.32

,,300,口服散剂,0.00,12.00,18.00,21.00,17.20,14.25,10.25,7.50,6.23,4.50,3.00,2.10,1.26,0.55,0.19

,,350,口服胶囊,0.00,3.30,6.25,8.40,11.00,10.50,10.00,7.60,6.20,4.50,2.95,2.10,1.25,0.54,0.19

,logC,300,静脉注射液,1.48,1.43,1.39,1.34,1.24,1.16,1.06,0.88,0.79,0.65,0.47,0.32,0.10,-0.27,-0.73

,,500,口服溶液,,1.48,1.54,1.54,1.46,1.38,1.27,1.10,1.02,0.88,0.70,0.54,0.32,-0.04,-0.49

,,300,口服散剂,,1.08,1.26,1.32,1.24,1.15,1.01,0.88,0.79,0.65,0.48,0.32,0.10,-0.26,-0.72

,,350,口服胶囊,,0.52,0.80,0.92,1.04,1.02,1.00,0.88,0.79,0.65,0.47,0.32,0.10,-0.27,-0.73

,r,300,静脉注射液,-1.0000,-1.0000,-1.0000,-1.0000,-1.0000,-1.0000,-1.0000,-1.0000,-1.0000,-1.0000,-1.0000,-1.0000,-1.0000,-1.0000,

,,500,口服溶液,,-0.9978,-0.9997,-0.9999,-1.0000,-0.9999,-0.9999,-0.9999,-0.9999,-0.9999,-0.9999,-1.0000,-1.0000,-1.0000,

,,300,口服散剂,,-0.9904,-0.9987,-0.9997,-0.9997,-0.9996,-0.9996,-0.9999,-0.9999,-0.9999,-0.9999,-1.0000,-1.0000,-1.0000,

,,350,口服胶囊,,-0.9100,-0.9635,-0.9839,-0.9953,-0.9978,-0.9994,-1.0000,-1.0000,-1.0000,-1.0000,-1.0000,-1.0000,-1.0000,

,AUC0-t,300,静脉注射液,,28.50,54.25,77.50,117.05,149.10,175.10,213.30,227.10,243.15,258.05,265.63,274.00,281.15,284.76

,mg/L×h,500,口服溶液,,15.00,47.50,82.50,146.25,198.75,241.25,303.75,326.63,353.44,378.44,391.19,405.19,417.27,423.47

,,300,口服散剂,,6.00,21.00,40.50,78.70,110.15,134.65,170.15,183.88,199.96,214.96,222.61,231.01,238.26,241.99

,,350,口服胶囊,,1.65,6.43,13.75,33.15,54.65,75.15,110.35,124.15,140.20,155.10,162.68,171.05,178.20,181.81

,AUMCo-t,300,静脉注射液,,13.50,51.50,109.00,262.75,452.00,657.00,1061.60,1253.40,1514.40,1806.20,1982.30,2207.30,2438.92,2585.59

,mg/L×h×h,500,口服溶液,,15.00,65.00,152.50,401.25,711.25,1046.25,1708.75,2026.88,2462.81,2952.81,3249.06,3625.31,4017.15,4268.75

,,300,口服散剂,,6.00,30.00,79.50,228.50,414.25,606.25,985.75,1176.63,1438.19,1732.19,1909.94,2135.69,2370.94,2522.09

,,350,口服胶囊,,1.65,9.55,28.40,108.60,237.10,400.60,778.20,970.00,1231.00,1522.80,1698.90,1923.90,2155.52,2302.19

,K,300,静脉注射液,,0.106,,,,,,,,,,,,,

,1/h,500,口服溶液,,0.105,,,,,,,,,,,,,

,,300,口服散剂,,0.105,,,,,,,,,,,,,

,,350,口服胶囊,,0.106,,,,,,,,,,,,,

,AUC0-∞,300,静脉注射液,,286.52,,,,,,,,,,,,,

,mg/L×h,500,口服溶液,,426.53,,,,,,,,,,,,,

,,300,口服散剂,,243.82,,,,,,,,,,,,,

,,350,口服胶囊,,183.56,,,,,,,,,,,,,

,AUMCo-∞,300,静脉注射液,,2686.36,,,,,,,,,,,,,

,mg/L×h×h,500,口服溶液,,4444.87,,,,,,,,,,,,,

,,300,口服散剂,,2627.20,,,,,,,,,,,,,

,,350,口服胶囊,,2402.77,,,,,,,,,,,,,

,MRT,300,静脉注射液,0-t,9.08,0-∞,9.38,,,,,,,,,,,

,h,500,口服溶液,,10.08,,10.42,,,,,,,,,,,

,,300,口服散剂,,10.42,,10.78,,,,,,,,,,,

,,350,口服胶囊,,12.66,,13.09,,,,,,,,,,,

,F,300,静脉注射液,,,,,,,,,,,,,,,

,%,500,口服溶液,,89.32,,,,,,,,,,,,,

,,300,口服散剂,,85.10,,,,,,,,,,,,,

,,350,口服胶囊,,54.92,,,,,,,,,,,,,

,MAT,300,静脉注射液,0-t,,0-∞,,,,,,,,,,,,

,h,500,口服溶液,,1.00,,1.05,,,,,,,,,,,

,,300,口服散剂,,1.34,,1.40,,,,,,,,,,,

,,350,口服胶囊,,3.58,,3.71,,,,,,,,,,,

,MDT,300,静脉注射液,0-t,,0-∞,,,,,,,,,,,,

,h,500,口服溶液,,,,,,,,,,,,,,,

,,300,口服散剂,,0.3