宠物内科疾病讲解用药皮肤病ia中文1canine pyoderma esavs guangzhou

Bacterialinfection:dogs&细 ：犬&nearlyallcaninepyodermaprincipalstaphylococcalpathogenincatsS.aureus,occasional-bewareofOtherstaphylococci–S.schleiferi,S.felisMultiplestrains&mixedinfections antibioticsensitivityofdifferentisolatesfromasingledogmayNotresidentsofskin-residentinsomeorall ,upperrespiratorytract,anus,vagina&prepuce;about70%ofdogs.口腔，上呼吸道， ThePathogenic

S.aureus-Sourcesof Sources&agentsLickingmucosalflora舔舐—Bitewoundsoralflora;–Faecalcontaminationgutflora—Moistlesions-gram-negatives潮湿病变–革兰 Inappropriatetherapy-yeasts,resistantContaminationfromvarioussourcessoilgutotheranimals-NocardiaActinomycesDermatophilusMycobacteriaHumansources?Typeof Primary&Secondary SecondarytreatmentmustdealwithunderlyingFewinfectionsarereally ClassificationofCaninePyodermaAcutemoistdermatitisSkin-foldpyodermaMicrobialovergrowthImpetigoFolliculitisSuperficialspreadingpyodermaMucocutaneouspyodermaDEEP Localisedfolliculitis&Generaliseddeepfolliculitis& Bacterialgranulomas InnotesisinsuperficialDavidLloyd,2005-7-

DermatophilosisDavidLloyd,2005-7-CaninePyoderma:PredisposingForeignbodiesEctoparasites

ProtozoaCaninePyoderma犬

Surface表 Superficial浅 FromLloyd&Halliwell(1998)CaninePyoderma.CLIVECD,SurfaceSAcutemoistDisruptionofNot Largelyself-inflicted很多病表rface表Underlyingpruriticfleaallergy, sacirritationotitis,foreignbodies,arthritis 耳炎，异物，关节炎LesionmayhidedeeperbacterialorfungalinfectionSurfacePyodermasTherapyClip&gentlycleanaffectedskincare Antisepticsorantibiotics&astringents杀菌剂或抗生素，和收Preventfurtherself-inflicteddamage+/-short-termanti- toryglucocorticoidSurfacePyodermasSkin-foldpyodermaPredisposingfactorsBreede.gbulldogsbassetsFace, ,tail, FrictionincreasedhumidityMicrobialovergrowthelevatedpopulationsofpathogenicstaphylococciSignsErythemaulcerationexudationvariablepruritusSurfaceInterdigitalspaces&digitalparticularlyinallergyrfaceFacial periocularfoldmaycauserfaceLipFoldLowerSurface rBitchesspayedbeforefirstoestrus&/orareforwardtodiagnose向前拉 SurfaceTailfold尾部褶皱BostonterrierBritishbulldogSurfaceBodyfoldsParticularlyaproblemofSharpei&obesedogsSurfacePyodermasSkin-foldpyodermaDiagnosisSignsUnderlyingexacerbatingfactor?潜在 Topicale.g.benzoyl-peroxide,Malaseb,Astringentsprays,wipesSeldomsystemicantibioticSurgerySurfacePyodermasMicrobialovergrowthMalasseziaovergrowth(“MOG”) MalasseziaBacterialovergrowthBOGSigns

MaybegreasyorscalyBassetthound巴吉

InterdigitaldermatitisincanineSurfaceSTreatmentChlorhexidine(+miconazoleifyeastBenzoylperoxidePiroctoneolamineandSystemicantibiotics–forseverecases全身性抗生素–用于严重的病例Monitoringessential CanineCaninePyodermaSuperficialFromFromLloyd&Halliwell(1998)CaninePyoderma.CLIVECD,Impetigo(“puppypyoderma”)PrepubescentPustules,non-Especiallyinguinum, MaybemildImpetigoRespondstoSystemicantibioticseldomImpetigorareinLookforunderlyinge.g.S浅uperficialS浅Superficial&deepCommoninespecially2otoPapules&pustules,targetlesions ficialIncludes“short-haireddogS浅uperficialS浅Papules&pustules,target SuperficialDiagnosisSignssmears,cultures;identifyunderlyingDifferentiateTreatmentSystemicantibiotic全身性给与抗生素until7-10dafterlesionsdisappear用至病变后7-10天才停止&/ortopicalshampoos,antibioticcreams&Mucocutaneouslips&adjacentskin嘴唇 的皮

diseaseisadifferentialAlsonares, ,prepuceand Painful,+/-ulceration&deepSometimesdepigmentationUsuallyneedssystemicMucocutaneouspyodermaMucocutaneouspyodermaMucocutaneouspyodermaFromLloydFromLloyd&Halliwell(1998)CaninePyoderma.CLIVECD,DeepPyodermaFurunculosis疖病CellulitisDeepFurunculosisFolliclesrupture,dermalinfection,foreignbodyreactionto LocalisedFacefeet,pressurepointsChin&muzzlefolliculitis&furunculosis(“acne”)下颚和口NasalpyodermaInterdigitalGeneralisedDeeppyodermaindemodicosis-facialDeepChin&muzzlefolliculitisusuallytransientbutMayextend&causecurefurunculosiswithtopicaltherapy5%benzoylperoxidegeltwicedailythen2-3timesperweekifsevere,topicalantibioticsfusidicDeep lusorPressure-pointOfteninlargebreedsofElbows,stifles,hocks,Crusting/mattingmayconcealulceration,drainingtractsUnderlyingproblem:pressure,bedding,ImprovemanagementAntibiotics,soaks,DeepAcrallickcranialaspectofdistal que+/-centralOrganicorfractureoffollicles,foreignbodyreactiontoAcrallickassumedeepprolongedantibioticsmanyweekstomonthsepNasalArisesveryDorsumofnoseswollen&鼻背部肿胀和疼痛，+/-红肿，TreatmentTBroadrangeofinfections,drugreactions,insectbite TrytoidentifyGeneralisedDeepSignsMayaffectmuchofthebodyPrurituspain MayrespondtotreatmentbutGeneralisedDeepIdentify&correctAntibiotics,cleansing,StaphylococcalDeep&SubcutaneousMoreoftenincatsespeciallybitewoundsStaphylococci,actinomycetes,ActinobacillusMycobacterialinfectionsAnaerobicbacteriaDeepmycoticinfectionDependsoncausedraining&surgeryusuallyneeded通常需 Resistanttomethicillinviathemecgenetoupto10differentantibiotics10种不同的mayhavesensitivityonlytoe.g. ycinmayresistbiocides:quaternarychlorhexidine,acridines EndemicinhumanhospitalsMulti-resistant butmostveterinaryisolatessensitivetopotentiatedsulphonamidesandtertacycline耐药谱宽，AlsotopicalagentsIncludingfusidicacidmupirocinMulti-resistantS.Maybemethicillin-resistantMayresistallexcepttopicalsNowemerginginEuropeCoagulase-negativesCommonlymultiresistantWhentoCytologyCultureDeeppyodermaRodsonFailuretorespondtoappropriateantimicrobialtherapy适当的抗生素治疗无效AntibioticEfficacySpectrumofactivityDrugdistributionLackofsideeffectsCostRouteofadministrationDosingfrequencyAntibioticTherapyinAntibioticDose剂量IntervalErythromycin8ycinUseinsurface&superficialAtleast2w至少用药2continue1wafterlesionsresolved在病 AntibioticTherapyin Interval用药间 Useindeep,severeorunresponsiveAtleast4w;continue2wafterlesionsAdjunctiveTherapyShampoosOintments,creamsandLotionsrinsesspraysOthersStaphylococcalvaccines葡萄球 ImmunostimulatorydrugsShampoosReducebacterialpopulationonRemovetissued