Tafasitamab-XmAb5574-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemETafasitamabCat.No.:HY-P9981CASNo.:1422527-84-1Synonyms:XmAb5574;MOR00208;Tafasitamab-cxix作⽤靶点:Apoptosis作⽤通路:Apoptosis储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Tafasitamab(XmAb5574)⼀种Fc修饰的⼈化单克隆抗体，可与⼈B细胞表抗原CD19结合。体外研究Tafasitamab(XmAb5574)inducescytotoxicityagainstMinoandJeko(MCL)celllinesinanE/Tratio-dependentmanner.Tafasitamab(XmAb5574)increasesADCPandantiproliferativeactivity.Tafasitamab(XmAb5574)enhancesantiproliferativeapoptoticactivityduetocaspase-inducedapoptosis[1][2].CellCytotoxicityAssay[1]CellLine:NHLcelllinesandprimaryCLLandMCLcellsbyγδTcellsConcentration:IncubationTime:2hResult:InducedkillingofNHLcelllinesandprimaryCLLandMCLcellsbyγδTcells.CellProliferationAssay[2]CellLine:SU-DHL-6cellsConcentration:IncubationTime:72hResult:Showedpotentantiproliferativeeffectsontumorcell.ApoptosisAnalysis[2]1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemECellLine:SU-DHL-6cellsConcentration:0-4ng/mLIncubationTime:48hResult:Showedpotentantiproliferativeeffectsduetocaspase-inducedapoptosis体内研究Tafasitamab(SC,onceonDay1,2.5μg/kg)inhibitslymphomagrowthindisseminatedBLmousexenografttumormodels[1].AnimalModel:DisseminatedRajimodel[1].Dosage:2.5μg/kgAdministration:Tafasitamab(SC,onceonDay1,2.5μg/kg)Result:ShowedantitumoractivityindisseminatedRajimodel.AnimalModel:DisseminatedRamosmodel[1].Dosage:10mg/kgAdministration:Tafasitamab(IV,onDays3,6,10,13,17,and20atadoseof10mg/kg)Result:ShowedantitumoractivityindisseminatedRamosmodel.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-379