Methoxamine-hydrochloride-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEMethoxaminehydrochlorideCat.No.:HY-B1298CASNo.:61-16-5分⼦式:C₁₁H₁₈ClNO₃分⼦量:247.72作⽤靶点:AdrenergicReceptor作⽤通路:GPCR/GProtein;NeuronalSignaling储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:240mg/mL(968.84mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM4.0368mL20.1841mL40.3682mL5mM0.8074mL4.0368mL8.0736mL10mM0.4037mL2.0184mL4.0368mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2mg/mL(8.07mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE2.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2mg/mL(8.07mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性Methoxaminehydrochloride⼀种选择性alpha1肾上腺素能受体激动剂。Methoxaminehydrochloride引起⾎管收缩和外周⾎管阻⼒增加。Methoxaminehydrochloride通过Prazosin敏感机制在兔肺动脉显著增加ATP、ADP和AMP的溢出，但不增加腺苷的溢出[3]。IC50&TargetNoradrenergicα1[1].体内研究Methoxamine(0.025mg/kg;femoralvein)hydrochloridehasagreatereffectonperipheralresistancevesselsthanonWinkesselvesselsintheratsystemiccirculation[2].AnimalModel:MaleWistar-Kyotoratsweighing320-47g(basedontheexponentiallytaperedT-tubemodel)[2]Dosage:0.025mg/kgAdministration:FemoralveinResult:HadagreatereffectontheperipheralresistancevesselsthanontheWinkesselvesselsintheratsystemiccirculation.REFERENCES[1].SandersAB.Therolesofmethoxamineandnorepinephrineinelectromechanicaldissociation.AnnEmergMed.1984;13(9Pt2):835-839.[2].ChangKC.Hypertensiveeffectsofmethoxamineonarterialmechanicsinrats:analysisbasedonexponentiallytaperedT-tubemodel.EurJPharmacol.1998;350(2-3):195-202.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.