Taurochenodeoxycholic-acid-sodium-salt-12-Deoxycholyltaurine-sodium-salt-DataSheet-生命科学试剂-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrarieswww.MedChemETaurochenodeoxycholicacidsodiumsaltCat.No.:HY-N1429CASNo.:6009-98-9Synonyms:12-Deoxycholyltaurinesodiumsalt分⼦式:C₂₆H₄₄NNaO₆S分⼦量:521.69作⽤靶点:Apoptosis;EndogenousMetabolite作⽤通路:Apoptosis;MetabolicEnzyme/Protease储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:100mg/mL(191.68mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.9168mL9.5842mL19.1685mL5mM0.3834mL1.9168mL3.8337mL10mM0.1917mL0.9584mL1.9168mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存⽅式和期限。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的⼯作液，建议您现⽤现配，当天使⽤；澄的储备液可以根据储存条件，适当保存；以下溶剂前的百分⽐指该溶剂在您配制终溶液中的体积占⽐)：1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(4.79mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.5mg/mL(4.79mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoil1/2MasterofSmallMolecules—您⾝边的抑制剂⼤师www.MedChemESolubility:≥2.5mg/mL(4.79mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性Taurochenodeoxycholicacidsodiumsalt(12-Deoxycholyltaurinesodiumsalt)动物胆汁酸的主⽣物活性物质之⼀。Taurochenodeoxycholicacid可诱导细胞凋亡(apoptosis)，并具有明显的抗炎和免疫调节作⽤。IC50&TargetHumanEndogenousMetabolite体外研究TaurochenodeoxycholicaciddramaticallyimprovestheapoptosisrateofNR8383cellsinaconcentration-dependentmanner.Inthemeantime,TaurochenodeoxycholicacidsignificantlyaugmentsPKCmRNAlevels,activitiesandincreasesJNK,caspase-3andcaspase-8mRNAexpressionlevels,activities[1].体内研究Taurochenodeoxycholicacid(0.05,0.1g/kg)decreasesthepulmonarycoefficientinthemodelmiceandreducesthepathologicaldamagesontheirlungs;itcandecreasetheexpressionlevelsofTNF-αandTIMP-2inpulmonarytissuesinthepulmonaryfibrosismiceandhasnosignificanteffectsonMMP2[2].Taurochenodeoxycholicacidsignificantlynormalizestheclinicalinflammatoryparameters,preventedindomethacin-inducedincreasesinthebiliarycontentsofsecondarybileacidsandhydrophobicityindex,andtendedtoattenuatetheintestinalinflammation[3].Taurochenodeoxycholicacidsignificantlysuppressespawswellingandpolyarthritisindex,increasesthelossbodyweightandindexofthymusandspleen,andamendsradiologicchangesinAArats.TheoverproductionandmRNAexpressionofTNF-α,IL-1βandIL-6areremarkablysuppressedinserumandsynoviumtissueofallTCDCA-treatedrats[4].REFERENCES[1].WangX,etal.TaurochenodeoxycholicacidinducesNR8383cellsapoptosisviaPKC/JNK-dependentpathway.EurJPharmacol.2016Sep5;786:109-15.[2].ZhouC,etal.Theeffectsoftaurochenodeoxycholicacidinpreventingpulmonaryfibrosisinmice.PakJPharmSci.2013Jul;26(4):761-5.[3].UchidaA,etal.Taurochenodeoxycholicacidamelioratesandursodeoxycholicacidexacerbatessmallintestinalinflammation.AmJPhysiol.1997May;272(5Pt1):G1249-57.[4].LiuM,etal.Effectsoftaurochenodeoxycholicacidonadjuvantarthritisinrats.IntImmunopharmacol.2011Dec;11(12):2150-8.McePdfHeightCaution:Producthasnotbeenfullyv