Tipepidine-hydrochloride-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemETipepidine hydrochlorideCat. No.: HY-121685ACAS No.: 1449686-84-3分式: CHClNS分量: 311.89作靶点: Dopamine Receptor作通路: GPCR/G Protein; Neuronal Signaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DM

2、SO : 41.67 mg/mL (133.60 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.2063 mL 16.0313 mL 32.0626 mL5 mM 0.6413 mL 3.2063 mL 6.4125 mL10 mM 0.3206 mL 1.6031 mL 3.2063 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性

3、，体内实验的作液，建议您现现配，当天使；澄的储备液可以根据储存条件，适当保存；以下溶剂前的百分指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (6.67 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (6.67 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oi

4、lSolubility: 2.08 mg/mL (6.67 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 Tipepidine hydrochloride 可逆地抑制多巴胺 D2 受体介导的 GIRK 电流 (IDA(GIRK)，从激活 VTA 多巴胺神经元， IC50 为 7.0 M。Tipepidine hydrochloride种醉性镇咳药，具有抗抑郁样作。IC50 & Target IC50: 7.0 M (dopamine D2 receptor)

5、1体内研究 Tipepidine (i.p.; 10-40 mg/kg; 0.5-23 hours) significantly decreases the immobility time in the forcedswimming test in ACTH-treated rats. Tipepidine (i.p.; 40 mg/kg) increases the extracellular dopamine level ofthe nucleus accumbens (NAc) in ACTH-treated rats 2.Animal Model: Male Wistar rats w

6、eighting 150-240 g (5-7 weeks old) 2Dosage: 10, 20 and 40 mg/kgAdministration: I.p.; 0.5, 5, 23 hoursResult: Decreased the immobility time in the forced swimming test in ACTH-treated rats.REFERENCES1. Hamasaki R, et al. Tipepidine activates VTA dopamine neuron via inhibiting dopamine D receptor-medi

7、ated inward rectifying K current.Neuroscience. 2013 Nov 12;252:24-34.2. Kawaura K, et al. Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect in the forced swimming test inadrenocorticotropic hormone-treated rats. Behav Brain Res. 2016 Apr 1;302:269-78.McePdfHeightCaution: Product has not been fully validated for medical applications.For research us