SIS17-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESIS17Cat. No.: HY-128918CAS No.: 2374313-54-7分式: CHNOS分量: 366.6作靶点: HDAC作通路: Cell Cycle/DNA Damage; Epigenetics储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 125 mg/mL (340.97 mM; Need ult

2、rasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.7278 mL 13.6388 mL 27.2777 mL5 mM 0.5456 mL 2.7278 mL 5.4555 mL10 mM 0.2728 mL 1.3639 mL 2.7278 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄的储备液可以根据储存条件，适当保

3、存；以下溶剂前的百分指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (5.67 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (5.67 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE物活性 SIS17哺乳动物组蛋去酰

4、化酶 11 (HDAC 11) 抑制剂，IC50 值为 0.83 M，抑制去甲酰化 HDAC 11 底物，丝氨酸羟甲转移酶 2，不抑制其他 HDAC。IC50 & Target IC50: 0.83 M (HDAC 11) 1REFERENCES1. Son SI, et al. Activity-Guided Design of HDAC11-Specific Inhibitors. ACS Chem Biol. 2019 Jul 19;14(7):1393-1397.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 021