Vancomycin-hydrochloride - Bacterial 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEVancomycin hydrochlorideCat. No.: HY-17362CAS No.: 1404-93-9分式: CHClNO分量: 1485.72作靶点: Bacterial; Autophagy作通路: Anti-infection; Autophagy储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 H2O : 33.33

2、mg/mL (22.43 mM; Need ultrasonic)DMSO : 24 mg/mL (16.15 mM; Need ultrasonic and warming)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 0.6731 mL 3.3654 mL 6.7307 mL5 mM 0.1346 mL 0.6731 mL 1.3461 mL10 mM 0.0673 mL 0.3365 mL 0.6731 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择

3、适当的溶解案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (1.68 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (1.68 mM); Clear sol

4、ution3. 请依序添加每种溶剂： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (1.68 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Vancomycin hydrochloride于治疗细 感染 (bacterial) 的抗素。 它通过抑制易感细的细胞壁合成的第阶段起作。 Vancomycin还改变细胞膜的渗透性并选择性地抑制核糖核酸的合成。IC50 & Target Bacterial 1体外研究 Vanco

5、mycin is a large glycopeptide compound with a molecular weight of 1450 Da 1. Vancomycin is aunique glycopeptide structurally unrelated to any currently available antibiotic. It also has a unique mode ofaction inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin is a

6、ctive againsta large number of species of Gram-positive bacteria, such as Staphylococcus aureus, Staph. epidermidis,Str. agalactiae, Str. bovis, Str. mutans, viridans streptococci, enterococci 2.体内研究 Vancomycin is administered intravenously, with a standard infusion time of at least 1 h, to minimize

7、 infusion-related adverse effects. Subjects with normal creatinine clearance, vancomycin has an -distribution phaseof 30 min to 1 h and a -elimination half-life of 6-12 h. The volume of distribution is 0.41 L/kg. The binding ofvancomycin to protein ranges from 10% to 50%. Factors that affect the ove

8、rall activity of vancomycin includeits tissue distribution, inoculum size, and protein-binding effects 1. Vancomycin treatment of infected mice isassociated with improved clinical, diarrhea, and histopathology scores and survival during treatment 3.PROTOCOLAnimal Mice: One set of experiments is perf

9、ormed in which infected mice are treated with vancomycin (50 mg/kg)Administration 3 daily for 1, 2, 3, or 5 days and are observed for 21 days postinfection or with vancomycin (20 mg/kg) daily foreither 5 or 10 days and monitoring for 15 days postinfection 3.MCE has not independently confirmed the ac

10、curacy of these methods. They are for reference only.户使本产品发表的科研献 Chemosphere. 2019 Mar.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Rybak MJ, et al. The pharmacokinetic and pharmacodynamic properties of vancomycin. Clin Infect Dis. 2006 Jan 1;42 Suppl 1:S35-9.2. Watanakunako

11、rn C, et al. Mode of action and in-vitro activity of vancomycin. J Antimicrob Chemother. 1984 Dec;14 Suppl D:7-18.3. Warren CA, et al. Vancomycin treatments association with delayed intestinal tissue injury, clostridial overgrowth, and recurrence ofClostridium difficile infection in mice. Antimicrob Agents Chemother. 2013 Feb;57(2):689-96.McePdfHeight2/2 Master of Small Molecules 您边的抑制剂师www.MedChemECaution: Product has