Bepotastine-Beslilate - Histamine Receptor Antagonist - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEBepotastine BeslilateCat. No.: HY-A0015CAS No.: 190786-44-8分式: CHClNOS分量: 547.06作靶点: Histamine Receptor作通路: GPCR/G Protein; Immunology/Inflammation; NeuronalSignaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C

2、 1 month溶解性数据体外实验 DMSO : 100 mg/mL (182.80 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.8280 mL 9.1398 mL 18.2795 mL5 mM 0.3656 mL 1.8280 mL 3.6559 mL10 mM 0.1828 mL 0.9140 mL 1.8280 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适

3、当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (4.57 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (4.57 mM); Clear so

4、lution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (4.57 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Bepotastine Beslilate (Bepreve)是组胺H1受体拮抗剂。REFERENCES1. Cho KH, Choi HG.Development of novel bepotastine salicylate salt bioequivalent to the

5、 commercial bepotastine besilate in beagledogs.Drug Dev Ind Pharm. 2012 Sep 10.2. Meier EJ, Torkildsen GL, Gow JA, McNamara TR, Gomes PJ, Williams JI; for the Bepotastine Besilate Ophthalmic Solutions StudyGroup.Integrated phase III trials of bepotastine besilate ophthalmic solution 1.5% for ocular

6、itching associated with allergicconjunctivitis.Allergy Asthma Proc. 2012 May;33(3):265-274.3. Kawakami T, Kimura S, Haga T, Doi R, Kyoya M, Nakagawa K, Soma Y.Health-related quality of life assessed by the effect ofbepotastine besilate in patients with pruritus: importance of emotions score in atopi

7、c dermatitis.J Dermatol. 2012 Jun;39(6):527-30.4. Williams JI, Kennedy KS, Gow JA, Torkildsen GL, Abelson MB, Gomes PJ, McNamara TR; Bepotastine Besilate Ophthalmic SolutionsStudy Group.Prolonged effectiveness of bepotastine besilate ophthalmic solution for the treatment of ocular symptoms of allerg

8、icconjunctivitis.J Ocul Pharmacol Ther. 2011 Aug;27(4):385-93. Epub 2011 Jun 7.5. Kida, Tetsuo; Fujii, Atsuko; Sakai, Osamu; Iemura, Masahito; Atsumi, Ikuyo; Wada, Tomoyuki; Sakaki, Hideyuki. Bepotastine besilate, ahighly selective histamine H1 receptor antagonist, suppresses vascular hyperpermeability and eosinophil recruitment in in vitro and in vivoexperimental allergic conjunctivitis models.Experimental Eye Research.Volume 91, Issue 1, July 2010, Pages 85-91McePdfHeightCaution: Product has not been fully validated for medical appl