纳米多孔羟基磷灰石的制备方法及其在药物载体方面应用的研究进展_图文

1、 1022 沈 阳 药 科 大 学 学 报 第 27 卷 26 TAYADE N G. Studies on nove l drug de live ry syste ms fo r anti m a larial drugs D . M aharashpra : M um ba, i 2006 . 27 CHO I W J , KI M J K, CHO I S H, e t a . l Low tox ic ity of catconic lipid based emu lsion for gene transfer J. B io m ater ials , 2004, 25( 27:

2、5893- 5903. 28 TAM ILVANAN S, SCHM IDT S, M LLER RH, et a.l In vitro adso rption o f plasm a pro teins onto the surface ( cha rges mod ified subm icroe m ulsion for intrav enous adm inistration J. Eur J Pha r m B iophar m, 2005 , 59 ( 1: 1- 7. 29 Y EEPRAE W, KAWAKAM I S, H I GU CH I Y, et a. l B io

3、distribution character istics o fm anno sy la ted and fucosy la ted O /W e m ulsions in m ice J . J D rug T arget , 2005, 13( 8- 9: 479- 487. Research progress on drug loaded intravenous lipid e m ulsions ZHAO M in g m ing, SU M in, TANG X ing ( Schoo l o f P ha r m acy, Shenyang Pharm aceutica l Un

4、 iversity, Shenyang 110016 , C hina Abstract : Objective T o summ ar ize th e research prog ress on drug lo aded in travenous lip id em ulsio ns as a nove l drug carrier . M ethods Represen tative papers recently pub lished w ere consulted , analyzed and summ a rized . R esults T he preparation m at

5、erials and techno logy, th e ev aluat io n m ethods, the clin ica l app lications and th e future pro spects w ere rev iew ed. Conclusion s T he drug loaded intravenous lip id em ulsio ns are prom ising fo r the further clin ica l applica tio n and have broad deve lop m ent in the future. K ey w ord

6、 s : drug loaded in travenous lip id e m ulsion ; preparation; app lication ( 上接第 1013 页 Research Progress on synthesis and characterization of nanoporous hydroxyapatite as drug carriers ZHAO Q in fu , ZH ENG L , i W ANG S i ling ( Schoo l o f P ha r m acy, Shenyang Pharm aceutica l Un iversity, She

7、nyang 110016 , C hina Abstract : Objective T o su mm arize the recen t preparat io n m ethod and the pace o f pro gre ss in th e nanopo rous hydroxyapatite as drug carries . M ethods B ased on re levant literatures , the la test researche s are repo rted . T he preparat io n m ethod and properties a

8、s carriesw ere rev iew ed , respectiv ely. R esu lts The m ain dev elop m en t tendency of nanoporous hydro xyapatite a s drug carriesw as po in ted ou. t C on clu sions N anopo ro us hydroxyap atite w ith variousm o rpho lo g ie s and surface properties hav e a lso been extensive ly applied as drug carriers o f a variety o f phar m aceut ica lm o lecules especially fo r biom acrom o lecules and inso lub le drug because o f th e ir ex ce llen t b io com pa tib ility, nontox ic ity, large specif