Ocifisertib-hydrochloride-CFI-400945-hydrochloride-生命科学试剂-MCE-6463

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEOcifisertibhydrochlorideCat.No.:HY-12300ACASNo.:1338799-83-9Synonyms:CFI-400945hydrochloride分⼦式:C₃₃H₃₅ClN₄O₃分⼦量:571.11作⽤靶点:Polo-likeKinase(PLK);Apoptosis作⽤通路:CellCycle/DNADamage;Apoptosis储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Ocifisertibhydrochloride(CFI-400945hydrochloride)Ocifisertib(HY-12300)的盐酸盐形式。Ocifisertibhydrochloride⼝服有效的PLK4抑制剂，Ki和IC50分别为0.26nM和2.8nM。Ocifisertibhydrochloride可抑制多种癌细胞的⽣长，在G2/M期阻滞细胞周期，并诱导细胞凋亡(apoptosis)。Ocifisertibhydrochloride在⼩⿏模型中表现出抗肿瘤活性。IC50&TargetPLK4TRKATRKBTIE2/TEK2.8nM(IC50)6nM(IC50)9nM(IC50)22nM(IC50)AURKB/INCENPAURKA98nM(IC50)140nM(IC50)户使⽤本产品发表的科研⽂献•NatNanotechnol.2021Jul;16(7):830-839.•IntJMolMed.2021Jan;47(1):151-160.•JCancerResClinOncol.2020Nov;146(11):2871-2883.•IrJMedSci.2022May4.Seemorecustomervalidationsonwww.MedChemEREFERENCES1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE[1].SampsonPB,etal.ThediscoveryofPolo-likekinase4inhibitors:identificationof(1R,2S).2-(3-((E).4-(((cis).2,6-dimethylmorpholino)methyl)styryl).1H.indazol-6-yl)-5?'-methoxyspiro[cyclopropane-1,3?'-indolin]-2?'-one(CFI-400945)asapotent,orallyactiveantitumoragent.JMedChem.2015Jan8;58(1):147-69.[2].MasonJM,etal.FunctionalcharacterizationofCFI-400945,aPolo-likekinase4inhibitor,asapotentialanticanceragent.CancerCell.2014Aug11;26(2):163-76.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-5895