β-Carotene-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEβ-Carotene(Standard)Cat.No.:HY-N0411RCASNo.:7235-40-7分⼦式:C₄₀H₅₆分⼦量:536.87作⽤靶点:EndogenousMetabolite;Apoptosis;ReactiveOxygenSpecies作⽤通路:MetabolicEnzyme/Protease;Apoptosis;Immunology/Inflammation;NF-κB储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性β-Carotene(Standard)β-Carotene的分析标准品。本产品⽤于研究及分析应⽤。β-Carotene(ProvitaminA)属于类胡萝⼘素化合物，天然存在的维⽣素A前体。β-Carotene⼀种ROS调节剂，具有抗氧化和抗炎活性。β-Carotene可作为抗氧化剂或者促氧化剂，取决于它的内在特性以及它所作⽤的⽣物环境的氧化还原电位。β-Carotene可诱导乳腺癌细胞凋亡(apoptosis)，具有抗癌活性[1][2][3][4][5]。IC50&TargetPPAR-γ,ROS,apoptosis[3]REFERENCES[1].Tanumihardjo,S.A.,Factorsinfluencingtheconversionofcarotenoidstoretinol:bioavailabilitytobioconversiontobioefficacy.IntJVitamNutrRes,2002.72(1):p.40-5.[2].Leo,M.A.,etal.Alcohol,vitaminA,andbeta-carotene:adverseinteractions,includinghepatotoxicityandcarcinogenicity.AmJClinNutr,1999.69(6):p.1071-85.[3].YanhongCui,etal.beta-Caroteneinducesapoptosisandup-regulatesperoxisomeproliferator-activatedreceptorgammaexpressionandreactiveoxygenspeciesproductioninMCF-7cancercells.EurJCancer.2007Nov;43(17):2590-601.[4].PaolaPalozza,etal.Prooxidanteffectsofbeta-caroteneinculturedcells.MolAspectsMed.2003Dec;24(6):353-62.[5].AKIFUMIKAWATA,etal.Anti-inflammatoryActivityofβ-Carotene,LycopeneandTri-n-butylborane,aScavengerofReactiveOxygenSpecies.InVivo.2018Mar-Apr;32(2):255-264.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-589