Y-27632-dihydrochloride-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEY-27632dihydrochloride(Standard)Cat.No.:HY-10583RCASNo.:129830-38-2分⼦式:C₁₄H₂₃Cl₂N₃O分⼦量:320.26作⽤靶点:ROCK;Organoid作⽤通路:CellCycle/DNADamage;Cytoskeleton;StemCell/Wnt;TGF-beta/Smad储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Y-27632(dihydrochloride)(Standard)Y-27632(dihydrochloride)的标准品。Y-27632dihydrochloride是⼀种具有⼝服活性的、ATP竞争性的ROCK(Rho-kinase)抑制剂(ROCK-IKi=220nM;ROCK-IIKi=300nM)。Y-27632dihydrochloride表现出抗癫痫的作⽤。•Science.2020Dec4;370(6521):eaay2002.•Nature.2022Nov;611(7936):603-613.•Nature.2022Jan;601(7894):600-605.•CancerCell.2024May20:S1535-6108(24)00164-8.•CancerCell.2023Jun12;41(6):1103-1117.e12.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].TadaS,etal.AselectiveROCKinhibitor,Y27632,preventsdimethylnitrosamine-inducedhepaticfibrosisinrats.JHepatol.2001Apr;34(4):529-36.[2].InanS,etal.AntiepilepticeffectsoftwoRho-kinaseinhibitors,Y-27632andfasudil,inmice.BrJPharmacol.2008Sep;155(1):44-51.[3].XueZW,etal.Rho-associatedcoiledkinaseinhibitorY-27632promotesneuronal-likedifferentiationofadulthumanadiposetissue-derivedstemcells.ChinMedJ(Engl).2012Sep;125(18):3332-5.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE[4].IshizakiT,etal.PharmacologicalpropertiesofY-27632,aspecificinhibitorofrho-associatedkinases.MolPharmacol.2000May;57(5):976-83.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58955