Rhodiosin-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemERhodiosin(Standard)Cat.No.:HY-N2425RCASNo.:86831-54-1分⼦式:C₂₇H₃₀O₁₆分⼦量:610.52作⽤靶点:Cholinesterase(ChE)作⽤通路:NeuronalSignaling储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Rhodiosin(Standard)Rhodiosin的分析标准品。本产品⽤于研究及分析应⽤。RhodiosinCYP2D6和AChE的双重抑制剂，能够从红景天根中分离得到，对CYP2D6的IC50为0.761μM，Ki为0.769μM。Rhodiosin具有抗氧化和神经保护活性，能够调节HIF-1α信号通路保护中枢神经系统[1][2][3][4]。IC50&TargetIC50:0.420μM(cytochromeP4502D6)[1]；57.50-2.43μg/mL(AChE)[2]；27.77μM(DPPHfreeradicalscavenging)[3]REFERENCES[1].XuW,etal.TwopotentcytochromeP4502D6inhibitorsfoundinRhodiolarosea.Pharmazie.2013Dec;68(12):974-6.[2].LiFJ,etal.MolecularinteractionstudiesofacetylcholinesterasewithpotentialacetylcholinesteraseinhibitorsfromtherootofRhodiolacrenulatausingmoleculardockingandisothermaltitrationcalorimetrymethods.IntJBiolMacromol.2017Nov;104(PtA):527-532.[3].YanX,etal.SalidrosideorchestratesmetabolicreprogrammingbyregulatingtheHif-1αsignallingpathwayinacutemountainsickness.PharmBiol.2021Dec;59(1):1540-1550.[4].KwonHJ,etal.Rhodiosin,anantioxidantflavonolglycosidefromRhodiolarosea.JournaloftheKoreanSocietyforAppliedBiologicalChemistry,2009,52:486-492McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax: