Methylene-Blue-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEMethyleneBlue(Standard)Cat.No.:HY-14536RCASNo.:61-73-4分⼦式:C₁₆H₁₈ClN₃S分⼦量:319.85作⽤靶点:GuanylateCyclase;MonoamineOxidase;NOSynthase;Microtubule/Tubulin作⽤通路:GPCR/GProtein;NeuronalSignaling;

Immunology/Inflammation;CellCycle/DNADamage;

Cytoskeleton储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性MethyleneBlue(Standard)MethyleneBlue的分析标准品。本产品⽤于研究及分析应⽤。Methyleneblue(BasicBlue9)⼀种鸟苷酸环化酶(sGC)，单胺氧化酶A(MAO-A)和NO合酶(NOS)抑制剂。Methyleneblueblue通过⼀氧化氮合成酶/鸟苷酸环化酶信号通路降低脉冲前抑制。Methyleneblue⼀种氧化还原循环化合物，能够穿过⾎脑屏障。MethyleneblueTau聚集抑制剂。亚甲蓝可减轻脑⽔肿，减弱⼩胶质细胞活化，减少神经炎症。IC50&TargetGuanylylcyclase(sGC)[1].MonoamineoxidaseA(MAO-A)[1].NOsynthase(NOS)[1]REFERENCES[1].KlamerD,et,al.Phencyclidine-inducedbehaviourinmicepreventedbymethyleneblue.BasicClinPharmacolToxicol.2004Feb;94(2):65-72.[2].HochgräfeK,et,al.Preventivemethylenebluetreatmentpreservescognitioninmiceexpressingfull-lengthpro-aggreganthumanTau.ActaNeuropatholCommun.2015May10;3:25.[3].FennAM,et,al.Methyleneblueattenuatestraumaticbraininjury-associatedneuroinflammationandacutedepressive-likebehaviorinmice.JNeurotrauma.2015Jan15;32(2):127-38.McePdfHeihtCaution:Producthasnotbeenfullyvalidatedformedicalapplications.gForresearchuseonly.Tel:400-820-3792ax:0