Trovafloxacin-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemETrovafloxacin(Standard)Cat.No.:HY-A0170RCASNo.:147059-72-1分⼦式:C₂₀H₁₅F₃N₄O₃分⼦量:416.35作⽤靶点:Bacterial;Topoisomerase;Antibiotic作⽤通路:Anti-infection;CellCycle/DNADamage储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Trovafloxacin(Standard)Trovafloxacin的分析标准品。本产品⽤于研究及分析应⽤。Trovafloxacin⼀种⼴谱喹诺酮类抗⽣素，对⾰兰⽒阳性，⾰兰⽒性和厌氧具有有效的活性。Trovafloxacin可阻断DNA促旋酶(DNAgyrase)和拓扑异构酶IV(topoisomeraseIV)的活性。Trovafloxacin也⼀种有效的，选择性的，⼝服活性的Pannexin1通道(PANX1)抑制剂，对PANX1内向电流的IC50为4μM。Trovafloxacin不抑制connexin43gapjunction或PANX2。Trovafloxacin通过抑制PANX1导致凋亡细胞碎⽚失调。IC50&TargetIC50:4μM(Pannexin1channel(PANX1))[2]Gram-positive,Gram-negativeandanaerobicorganisms[3]DNAgyrase[3]TopoisomeraseIV[3]REFERENCES[1].GiustariniG,etal.ThehepatotoxicfluoroquinolonetrovafloxacindisturbsTNF-andLPS-inducedp65nucleartranslocationinvivoandinvitro.ToxicolApplPharmacol.2020Mar15;391:114915.[2].PoonIK,etal.Unexpectedlinkbetweenanantibiotic,pannexinchannelsandapoptosis.Nature.2014Mar20;507(7492):329-34.[3].GootzTD,etal.Activityofthenewfluoroquinolonetrovafloxacin(CP-99,219)againstDNAgyraseandtopoisomeraseIVmutantsofStreptococcuspneumoniaeselectedinvitro.AntimicrobAgentsChemother.1996Dec;40(12):2691-7.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792a