Tilorone-dihydrochloride-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemETiloronedihydrochloride(Standard)Cat.No.:HY-B1080RCASNo.:27591-69-1分⼦式:C₂₅H₃₆Cl₂N₂O₃分⼦量:483.47作⽤靶点:HIF/HIFProlyl-Hydroxylase;InfluenzaVirus作⽤通路:MetabolicEnzyme/Protease;Anti-infection储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Tilorone(dihydrochloride)(Standard)Tilorone(dihydrochloride)的分析标准品。本产品⽤于研究及分析应⽤。Tiloronedihydrochloride⼀种具有⼝服活性的⼲扰素(IFN)诱导剂，具有⼴谱抗病毒活性。Tiloronedihydrochloride通过刺激宿主先天免疫，在体外和体内具有强⼤的抗发热伴⾎⼩板减少综合征病毒(SFTSV)活性。Tiloronedihydrochloride可以透过⾎脑屏障，激活中枢神经系统中的HIF。Tiloronedihydrochloride对于埃博拉病毒具有抑制作⽤，EC50为230nM[4]。REFERENCES[1].JingjingYang,etal.Tiloroneconfersrobustinvitroandinvivoantiviraleffectsagainstseverefeverwiththrombocytopeniasyndromevirus.VirolSin.2022Feb;37(1):145-148.[2].SeanEkins,etal.Tilorone,aBroad-SpectrumAntiviralforEmergingViruses.AntimicrobAgentsChemother.2020Apr21;64(5):e00440-20.[3].RajivRRatan,etal.Smallmoleculeactivationofadaptivegeneexpression:tiloroneoritsanalogsarenovelpotentactivatorsofhypoxiainduciblefactor-1thatprovideprophylaxisagainststrokeandspinalcordinjury.AnnNYAcadSci.2008Dec:1147:383-94.[4].EkinsS,etal.,EfficacyofTiloroneDihydrochlorideagainstEbolaVirusInfection.AntimicrobAgentsChemother.2018Jan25;62(2):e01711-17.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792