Taurohyodeoxycholic-acid-d4-sodium-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemETaurohyodeoxycholicacid-d4sodiumCat.No.: HY-114360AS1分子式: C₂₆H₄₅NO₆S.xNa作用靶点: Isotope-LabeledCompounds;TNFReceptor;InterleukinRelated作用通路: Others;Apoptosis;Immunology/Inflammation储存方式: PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Taurohyodeoxycholicacid-d4(sodium)是氘代标记的Taurohyodeoxycholicacid(sodium)。Taurohyodeoxycholicacid(THDCA)sodium是二级胆汁酸羟基去氧胆酸的牛磺酸共轭形式。Taurohyodeoxycholicacid还能降低TNBS诱导的溃疡性结肠炎小鼠模型中髓过氧化物酶、TNF-α和IL-6的活性和表达，以及抑制结肠损伤。体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs[1].体内研究Taurohyodeoxycholicacidreducesthesizeandweightofhumangallstonesinvitro.Taurohyodeoxycholicacidincreasesbileflow,bilecholesterolsecretionandbilelipidsecretioninrats.Co-administrationofTaurohyodeoxycholicacidandTaurochenodeoxycholicacidpreventedTaurohyodeoxycholicacid-inducedhepatotoxicityandincreasedbileflowandbileacidandphospholipidsecretioninrats.REFERENCESRodaA,etal.Taurohyodeoxycholicacidprotectsagainsttaurochenodeoxycholicacid-inducedcholestasisintherat.Hepatology.1998Feb;27(2):520-5.AngelicoM,etal.Dissolutionofhumancholesterolgallstonesinbilesalt/lecithinmixtures:effectofbilesalthydrophobicityandvariouspHs.ScandJGastroenterol.1995Dec;30(12):1178-85.AngelicoM,etal.Effectoftaurohyodeoxycholicacid,ahydrophilicbilesalt,onbilesaltandbiliarylipidsecretionintherat.DigDisSci.1994Nov;39(11):2389-97.SolmonKusumaS,etal.Antineoplasticactivityofmonocrotalineagainsthepatocellularcarcinoma[J].Anti-CancerAgentsinMedicinalChemistry(FormerlyCurrentMedicinalChemistry-Anti-CancerAgents),2014,14(9):1237-1248.1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemERussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019Feb;53(2):211-216.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchus